ArticleNature communications2026
Circulating extracellular microRNAs as tissue-specific biomarkers of human health and disease.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- TheNon-coding RNA · 2026Article
- Circulating extracellular microRNAs as tissue-specific biomarkers of human health and disease.Nature communications · 2026Article
- Host miRNA orchestration of mitophagy pathways during bacterial infection: current advances and future directions.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Early pathological changes in many organ systems are difficult to detect, which creates challenges in disease prevention, diagnosis, and treatment. Here, we leverage circulating extracellular microRNAs (ex-miRNAs) to derive miRNA-based Tissue Signal (miR-TS) scores that simultaneously assess 17 tissues, including the brain, heart, liver, and lungs. Across three population-based cohorts and 10 clinical populations, miR-TS scores were robustly associated with relevant health outcomes with high tissue specificity. Using prospective data, miR-TS scores for the heart, brain, and lungs also functioned as predictive biomarkers that tracked the development of major health events, including acute myocardial infarction, cerebrovascular accidents, cognitive impairment, and airflow limitation. Finally, we demonstrated the utility of miR-TS scores in detecting tissue-specific toxicities from both acute and long-term exogenous exposures. Our results highlight the potential of circulating ex-miRNAs to function as robust biomarkers of tissue health and predict the onset of a wide range of diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.