Evidence map›Paper›PMID 42045243›Full record

ArticleNature communications2026

CFTR mediates Cl

Peijie Hu, Wanting Du, Muyan Chu, Junjiang Chen, Xiaotian Zhang, Ziyi Chen, Jun Hu, Lei Qin, Wayne Yuk-Wai Lee, Jinghui Guo and 8 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Peijie Hu *Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China.ORCID http://orcid.org/0009-0009-1355-7645
Wanting Du *Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
Muyan Chu *Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
Junjiang ChenDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
Xiaotian ZhangDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
Ziyi ChenDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
Jun HuFirst Affiliated Hospital, Shantou University Medical College, Shantou, China.
Lei QinDepartment of Orthopaedics, Shenzhen Nanshan People's Hospital, the Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, China.ORCID http://orcid.org/0000-0002-7712-9449
Wayne Yuk-Wai LeeMusculoskeletal Research Laboratory, Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0002-0486-360X
Jinghui GuoSchool of Medicine, The Chinese University of Hong Kong, Shenzhen, China.
Hui ChenDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China.ORCID http://orcid.org/0000-0002-7218-9047
Ruiyao XuDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
Xiaojun CaiDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China.
Xiaohua JiangEpithelial Cell Biology Research Centre, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Hsiao Chang ChanEpithelial Cell Biology Research Centre, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Ling QinMusculoskeletal Research Laboratory, Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China. lingqin@cuhk.edu.hk.ORCID http://orcid.org/0000-0001-6173-6167
Jiankun XuMusculoskeletal Research Laboratory, Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China. jiankunxu@cuhk.edu.hk.ORCID http://orcid.org/0000-0003-0280-9930
Ye Chun RuanDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China. sharon.yc.ruan@polyu.edu.hk.ORCID http://orcid.org/0000-0002-4266-6789

Funding

Food and Health Bureau of the Government of the Hong Kong Special Administrative Region | Health and Medical Research Fund (HMRF) 15161441Food and Health Bureau of the Government of the Hong Kong Special Administrative Region | Health and Medical Research Fund (HMRF) 18191361Research Grants Council, University Grants Committee (RGC, UGC) AoE/M-402/20Research Grants Council, University Grants Committee (RGC, UGC) T13-402/17N
6 · The paper itself

Abstract

Osteocytes are long-lived with underlying mechanisms largely unknown. Here, we report that osteocyte-specific knockout of cystic fibrosis transmembrane conductance regulator (CFTR) results in excessive osteocyte death, proinflammatory cytokine surge, osteoclast overactivation and bone formation impairment leading to bone loss in adult mice. Consistently in MLO‑Y4 osteocyte‑line, CFTR-knockout causes progressive cell death, which is reversed by CFTR overexpression or medium replenishment. A massive proinflammatory osteocyte secretome is evoked by CFTR-knockout, which deteriorates wild-type osteocytes, inhibits osteogenic differentiation, while robustly stimulates osteoclastogenic differentiation in vitro. Patch-clamp/Cl

Indexed as

Bone and BonesChloridesCystic Fibrosis Transmembrane Conductance RegulatorHomeostasisOsteocytesAnimalsCell DifferentiationCell LineCell SurvivalHumansMaleMiceMice, KnockoutOsteoclastsOsteogenesisCftr protein, mouseChloridesCystic Fibrosis Transmembrane Conductance Regulator

Identifiers

PMID42045243
PMCPMC13332021

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.