ArticleNature communications2026
Probing molecular diversity and ultrastructure of brain cells with fluorescent aptamers.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Detergent-free immunolabeling has been proven feasible for volumetric correlated light and electron microscopy (vCLEM) with the application of small immunoprobes, providing a reliable method to superimpose essential molecular information of cells onto their high-resolution electron microscopic images. However, the application of this method is restricted by the availability of suitable affinity reagents. Here we introduce CAptVE, a method using slow off-rate modified aptamers for cell fluorescence labeling on ultrastructurally reconstructable electron micrographs. CAptVE provides labeling for a wide range of biomarkers, offering a pathway to integrate molecular analysis into volumetric electron microscopic studies of tissues, including neural circuit investigations via connectomics.
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