ArticleNature communications2026
Balancing acceleration and turnover in [1 + 1] tetra-imine bis-calix[4]pyrrole reactor for Huisgen cycloadditions.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Tailored molecular cages can confine reactive partners and enhance their reaction rates. However, for bimolecular reactions, product inhibition is commonly observed. We report a tetra-imine bis-calix[4]pyrrole cage with two chemically non-equivalent polar hemispheres that promote azide-alkyne Huisgen cycloadditions. This cage forms 1:1 and 1:2 complexes with para-substituted pyridine-N-oxides, including ternary hetero-complexes with an azide and an alkyne moiety into proximity. Here, we show that cage confinement accelerates the regioselective formation of 1,4-triazoles. A global kinetic model allows the determination of the intra-vessel rate constant (k
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.