Evidence map›Paper›PMID 42045181›Full record

ReviewNature communications2026

The history and function of a circular RNA.

Cledi A Cerda-Jara, Flavia Scoyni, Grygoriy Zolotarov, Poojashree Bhaskar, Daniel León-Periñán, Jørgen Kjems, Nikolaus Rajewsky

Abstract readReview
In one paragraph

Review in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Target, silence, replace: a review on RNA-based drugs in modern medicine.Frontiers in cell and developmental biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cledi A Cerda-Jara *Laboratory for Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology Max Delbrück Centre for Molecular Medicine Hannoversche Str. 28 10115, Berlin, Germany.ORCID http://orcid.org/0000-0003-1783-5533
Flavia Scoyni *Laboratory for Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology Max Delbrück Centre for Molecular Medicine Hannoversche Str. 28 10115, Berlin, Germany.
Grygoriy ZolotarovCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Poojashree BhaskarLaboratory for Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology Max Delbrück Centre for Molecular Medicine Hannoversche Str. 28 10115, Berlin, Germany.
Daniel León-PeriñánLaboratory for Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology Max Delbrück Centre for Molecular Medicine Hannoversche Str. 28 10115, Berlin, Germany.ORCID http://orcid.org/0000-0002-7970-0362
Jørgen KjemsDepartment of Molecular Biology and Genetics (MBG), Aarhus University, Aarhus, Denmark.
Nikolaus RajewskyLaboratory for Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology Max Delbrück Centre for Molecular Medicine Hannoversche Str. 28 10115, Berlin, Germany. rajewsky@mdc-berlin.de.ORCID http://orcid.org/0000-0002-4785-4332

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cdr1as/ciRS-7 is a circular RNA conserved in mammals and highly expressed in brain. It features a large number of microRNA target sites bound in vivo by miR-7/miR-671. Cdr1as regulates synaptic activity under stress in a temporal, spatial, and neuron-specific manner. We review genetic, molecular, evolutionary, and physiological data to discuss how Cdr1as and its interactors form a functionally important network of non-coding RNAs that regulates neuronal adaptability. We provide a framework to explore potential roles of other non-coding RNA networks on brain function and their diagnostic and therapeutic potential.

Indexed as

RNA, CircularRNA, Long NoncodingAnimalsEvolution, MolecularHumansMammalsMicroRNAsNeuronslong non-coding RNA CDR1AS, humanMicroRNAsMIRN671 microRNA, humanMIRN7-1 microRNA, humanRNA, CircularRNA, Long Noncoding

Identifiers

PMID42045181
PMCPMC13125240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.