Evidence map›Paper›PMID 42045170›Full record

ArticleBone research2026

Vitamin K-dependent carboxylation in osteoblasts regulates bone resorption through GAS6 in male mice.

Monica Pata, Diep Ngoc Thi Pham, Julie Lacombe, B Ashok Reddy, Young Woong Kim, Abeer Gamal Ali Ahmed, Monzur Murshed, Mathieu Ferron

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Monica PataMolecular Physiology Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.
Diep Ngoc Thi PhamMolecular Physiology Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.
Julie LacombeMolecular Physiology Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.
B Ashok ReddyMolecular Physiology Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.
Young Woong KimMolecular Physiology Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.
Abeer Gamal Ali AhmedFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montréal, QC, Canada.ORCID 0000-0002-6092-1579
Monzur MurshedFaculty of Dental Medicine and Oral Health Sciences, McGill University, Montréal, QC, Canada.
Mathieu FerronMolecular Physiology Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada. mathieu.ferron@ircm.qc.ca.ORCID 0000-0002-5858-2686

Funding

Canada Research Chairs (Chaires de recherche du Canada) NAFonds de Recherche du Québec - Santé (Fonds de la recherche en sante du Quebec) NAGouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-159534
6 · The paper itself

Abstract

Studies in humans suggest that vitamin K is involved in the regulation of bone remodeling, but the precise mechanism at play remains unknown. In cells, vitamin K functions as a co-factor for the γ-glutamyl carboxylase (GGCX), an enzyme responsible for the conversion of glutamic acid residues (Glu) into γ-carboxyglutamic acid (Gla) residues in secreted proteins. We aim here at determining the role of γ-carboxylation in bone remodeling and at identifying the Gla protein(s) involved. We show that male mice lacking γ-carboxylation specifically in osteoblasts (Ggcx

Indexed as

Bone ResorptionIntercellular Signaling Peptides and ProteinsOsteoblastsVitamin KAnimalsAxl Receptor Tyrosine KinaseCarbon-Carbon LigasesCell Differentiationc-Mer Tyrosine KinaseCoculture TechniquesGrowth Arrest-Specific Protein 6MaleMiceOsteoclastsProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesAxl Receptor Tyrosine KinaseAXL receptor tyrosine kinase, mouseCarbon-Carbon Ligasesc-Mer Tyrosine Kinaseglutamyl carboxylaseGrowth Arrest-Specific Protein 6Intercellular Signaling Peptides and ProteinsProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesVitamin K

Identifiers

PMID42045170
PMCPMC13121459

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.