Evidence map›Paper›PMID 42045152›Full record

ArticleCell death & disease2026

Pi4ka downregulation triggers Creb3l2-dependent lysosomal dysfunction to promote maladaptive tubular remodeling and immune activation in acute kidney injury.

Zhimin Chen, Jingzhi Xie, Chengkun Wu, Keng Ye, Yue Chen, Yankun Song, Huabin Ma, Jianfeng Wu, Li Chen, Yanfang Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhimin Chen *Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.ORCID http://orcid.org/0000-0002-4260-1774
Jingzhi Xie *Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Chengkun Wu *School of Medicine, Nankai University, Tianjin, China.
Keng YeDepartment of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.ORCID http://orcid.org/0000-0002-3661-3664
Yue ChenCentral Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Yankun SongDepartment of Pathology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Huabin MaCentral Laboratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.ORCID http://orcid.org/0000-0002-0581-4615
Jianfeng WuLaboratory Animal Research Center, Xiamen University, Xiameng, 361000, China.ORCID http://orcid.org/0000-0002-8992-2030
Li ChenDepartment of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. chenlify@fjmu.edu.cn.
Yanfang XuDepartment of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. xuyanfang99@hotmail.com.ORCID http://orcid.org/0000-0002-6207-545X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82400784National Natural Science Foundation of China (National Science Foundation of China) 82570796
6 · The paper itself

Abstract

Acute kidney injury (AKI) is driven by maladaptive tubular responses, yet upstream regulators remain incompletely understood. Here, we identify phosphatidylinositol 4-kinase alpha (Pi4ka) as a critical determinant of proximal tubule cell (PTC) homeostasis and injury progression. PI4KA expression was reduced in human diseased kidneys and negatively correlated with renal function. Single-cell RNA sequencing in mouse models revealed that Pi4ka deficiency preferentially perturbs specific PTC states, including Slc34a1

Indexed as

Acute Kidney InjuryKidney Tubules, ProximalLysosomesAnimalsAutophagyBasic-Leucine Zipper Transcription FactorsDown-RegulationEndoplasmic Reticulum StressHumansMaleMiceMice, Inbred C57BLBasic-Leucine Zipper Transcription FactorsCREB3L2 protein, human

Identifiers

PMID42045152
PMCPMC13250169

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.