Evidence map›Paper›PMID 42045079›Full record

ArticleChemical research in toxicology2026

New Docking, Molecular Dynamics, and QSAR Models to Predict Disruption of Human and Rat Transthyretin Function by Per- and Polyfluoroalkyl Substances (PFAS).

Nuno M S Almeida, Heather M Bolstad, Scott Coffin, Sana Majid, Angela K Wilson, Anatoly A Soshilov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nuno M S AlmeidaNew Toxicology Evaluations Section (NTES), Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, 1001 I St, Sacramento, California 95814, United States.ORCID 0000-0002-6091-7289
Heather M BolstadNew Toxicology Evaluations Section (NTES), Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, 1001 I St, Sacramento, California 95814, United States.ORCID 0009-0006-9019-8971
Scott CoffinNew Toxicology Evaluations Section (NTES), Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, 1001 I St, Sacramento, California 95814, United States.ORCID 0000-0002-7035-1282
Sana MajidNew Toxicology Evaluations Section (NTES), Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, 1001 I St, Sacramento, California 95814, United States.ORCID 0000-0002-9968-0178
Angela K WilsonDepartment of Chemistry, Michigan State University, East Lansing, Michigan 48864, United States.ORCID 0000-0001-9500-1628
Anatoly A SoshilovNew Toxicology Evaluations Section (NTES), Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, 1001 I St, Sacramento, California 95814, United States.ORCID 0009-0002-6507-2657

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent chemicals that require an improved understanding of the toxicity mechanisms and the development of predictive models for risk assessment. One observed effect of PFAS exposure is a decrease in thyroxine (T

Indexed as

FluorocarbonsMolecular Docking SimulationMolecular Dynamics SimulationPrealbuminQuantitative Structure-Activity RelationshipAnimalsHumansRatsThyroxineFluorocarbonsPrealbuminThyroxine

Identifiers

PMID42045079
PMCPMC13188166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.