ArticleYonsei medical journal2026
Statin-Associated Hepatotoxicity Linked to
Article in Yonsei medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
Funding
Abstract
purposeStatins are widely used for cardiovascular diseases, but statin-associated hepatotoxicity remains a concern. Apoptotic caspases, including caspase-8 (CASP8) and caspase-3 (CASP3), are crucial in hepatotoxicity and may affect statin-associated hepatotoxicity. We examined how these gene variants affect hepatotoxicity risk and protein expression in statin users. MATERIALS AND
methodsWe retrospectively analyzed prospectively collected samples from 851 South Korean statin users to assess associations between
resultsAmong 851 patients, 66 experienced hepatotoxicity. In Model 1, lipophilic statins, atrial fibrillation, and diabetes mellitus were significantly associated with hepatotoxicity. In Model 2, three
conclusion
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