Evidence map›Paper›PMID 42044884›Full record

ArticleEmerging infectious diseases2026

Updated Genomic Epidemiologic Description of Candida (Candidozyma) auris, United States.

Lindsay A Parnell, Amanda Ribeiro Dos Santos, Kaitlin Forsberg, Meghan Lyman, Elizabeth Misas, Lalitha Gade, D Joseph Sexton, Anastasia P Litvintseva, Nancy A Chow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lindsay A Parnell
Amanda Ribeiro Dos Santos
Kaitlin Forsberg
Meghan Lyman
Elizabeth Misas
Lalitha Gade
D Joseph Sexton
Anastasia P Litvintseva
Nancy A Chow

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The multidrug-resistant yeast Candida (Candidozyma) auris has caused several healthcare-associated outbreaks in the United States. We provide a genomic epidemiologic description of 1,535 C. auris isolates collected in the United States during 2013-2022. We identified clades I, II, III, and IV but not clades V or VI. Median pairwise single-nucleotide polymorphism distances indicated lower intraclade relatedness for clades I (91), III (43), and IV (43), compared with clade II (1,455). Phylogenetic analysis showed regional clusters with varying predominant clades. Of 809 isolates that underwent antifungal susceptibility testing, 53 were echinocandin resistant, distributed across 3 clades; 92% (49/53) had FKS1 hotspot mutations, which varied regionally. Our findings corroborate ongoing transmission and clonal expansion of C. auris, likely propagated by multiple introductions within and between geographic regions. Echinocandin resistance in multiple clades highlights the need to increase awareness, improve treatment practices, and engage in rapid public health response.

Indexed as

Candida aurisCandidiasisGenome, FungalAntifungal AgentsDrug Resistance, FungalEchinocandinsGenomicsHumansMicrobial Sensitivity TestsPhylogenyPolymorphism, Single NucleotideUnited StatesAntifungal AgentsEchinocandinsantifungal resistanceantimicrobial resistanceCandida aurisCandidozyma aurisechinocandin resistanceFKS1fungigenomic epidemiologyUnited Stateswhole-genome sequencing

Identifiers

PMID42044884
PMCPMC13174969

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.