Evidence map›Paper›PMID 42044742›Full record

ArticleJournal of the Academy of Nutrition and Dietetics2026

Application of the Total Nutrient Index as a Precision Nutrition Tool to Address Dietary Recommendations Across the Life Course.

Alexandra E Cowan-Pyle, Janet A Tooze, Lindsay M Reynolds, Jaime J Gahche, Johanna T Dwyer, Diane C Mitchell, Raymond J Carroll, Bani K Mallick, Regan L Bailey

Abstract read
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Article in Journal of the Academy of Nutrition and Dietetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Alexandra E Cowan-PyleInstitute for Connecting Nutrition and Health, Florida State University, Tallahassee, Florida; Department of Behavioral Sciences and Social Medicine, College of Medicine, Florida State University, Tallahassee, Florida. Electronic address: aecowan@fsu.edu.
Janet A ToozeDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Lindsay M ReynoldsDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Jaime J GahcheOffice of Dietary Supplements, National Institutes of Health, Bethesda, Maryland.
Johanna T DwyerJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.
Diane C MitchellInstitute for Advancing Health Through Agriculture, Texas A&M AgriLife Research, Texas A&M University System, College Station, Texas.
Raymond J CarrollDepartment of Statistics, Texas A&M University, College Station, Texas.
Bani K MallickDepartment of Statistics, Texas A&M University, College Station, Texas.
Regan L BaileyInstitute for Connecting Nutrition and Health, Florida State University, Tallahassee, Florida; Department of Behavioral Sciences and Social Medicine, College of Medicine, Florida State University, Tallahassee, Florida.

Funding

Development of a Total Nutrient IndexU01CA215834 · NCI · TEXAS A&M AGRILIFE RESEARCH · PI REGAN BAILEY, JANET A. TOOZE · 2017 to 2026
$2.2M
NCI NIH HHS U01 CA215834
6 · The paper itself

Abstract

backgroundIndexes are a standardized tool for assessing dietary exposures from foods/beverages (F&B) and have recently been extended to include dietary supplements (DS). The Total Nutrient Index (TNI) (F&B + DS) and the Food Nutrient Index (FNI) (F&B only) were developed to assess micronutrient intakes relative to Dietary Reference Intakes for micronutrients and were previously examined for relative validity among US adults.

objectiveThis study examined the micronutrient quality (ie, TNI and FNI) of the diet across all age groups and compared TNI and FNI total and component scores with Healthy Eating Index 2020 scores among the US population. This analysis also sought to demonstrate the flexibility of the TNI and FNI frameworks across the life course.

designA nationally representative, cross-sectional analysis of the 2015-2020 National Health and Nutrition Examination Survey demographic, dietary, and dietary supplement data (ie, 24-hour dietary recall and DS inventory) was conducted among the US population. PARTICIPANTS AND

settingThis study included US adults and children (aged 1 year and older; n = 19 903) who participated in the 2015-2020 National Health and Nutrition Examination Survey. MAIN OUTCOMES: The main outcome measures were TNI and FNI total and component scores (range = 0 to 100) overall and by age group, with higher scores indicating greater adherence to the Dietary Reference Intakes. STATISTICAL ANALYSES PERFORMED: TNI and FNI scores were calculated via the simple algorithm method, for 11 age group-dependent micronutrients (calcium, choline, magnesium, phosphorus, potassium, and vitamins A, B12, C, D, E, and K), and compared with Healthy Eating Index 2020 scores.

resultsAmericans scored 72 out of 100 on TNI, but scores varied by age and were higher for the TNI than FNI (∼3 to 11 points.). Younger children (aged 1 to 3 years, TNI = 87; aged 4 to 8 years, TNI = 82) and older adults (aged 71 years and older, TNI = 77) exhibited higher TNI scores than other ages, due to higher calcium, magnesium, and vitamins A, C, and B12 intake. Healthy Eating Index 2020 total scores were low (52) overall and followed similar scoring trajectories by age group as the TNI and FNI.

conclusionsEvaluating total dietary exposures is important, considering the differential intake patterns from F&B, vs those with DS. Given low Dietary Reference Intakes adherence for some nutrients across the life span, these findings warrant improved diet quality and micronutrient density for many, to optimize nutrition and reduce diet-related chronic disease risk among Americans.

Indexed as

DietDiet, HealthyMicronutrientsNutrition AssessmentRecommended Dietary AllowancesAdolescentAdultAgedChildChild, PreschoolCross-Sectional StudiesDietary SupplementsFemaleHumansInfantMaleMicronutrientsDietary Reference IntakesDietary SupplementsMicronutrientsNHANESTotal Nutrient Index

Identifiers

PMID42044742
PMCPMC13575888

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.