Lateral Ridge Augmentation Using Low-dosage Bone Morphogenetic Protein-2 Functionalised Calcium Phosphate Cement.

Lingfei Wei, Yuanyuan Sun, Yiqun Wu, Zhonghao Liu, Yuelian Liu

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Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Lingfei WeiDepartment of Oral Implantology, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai, China; Department of Second Dental Center, Shanghai Ninth People's Hospital, School of Medicine; College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, China; Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, the Netherlands. Electronic address: weilingfei@hotmail.com.

Yuanyuan SunDepartment of Second Dental Center, Shanghai Ninth People's Hospital, School of Medicine; College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, China; Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, the Netherlands.

Yiqun WuDepartment of Second Dental Center, Shanghai Ninth People's Hospital, School of Medicine; College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, China.

Zhonghao LiuDepartment of Oral Implantology, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai, China.

Yuelian LiuDepartment of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo evaluate bone regeneration and osseointegration using low-dosage Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2) incorporated with calcium phosphate cement (CPC) via a biomimetic coating method during simultaneous lateral ridge augmentation with implant placement. MATERIALS AND

methodsChronic horizontal alveolar bone defects were created in the mandibles of 5 dogs. Before implant placement, defects were randomly assigned to different grafting groups: autologous bone, CPC, high-dosage ErhBMP-2 (1088 µg/g) adsorbed to CPC (ErhBMP-2 Ads. CPC), and low-dosage ErhBMP-2 (239 µg/g) incorporated with CPC (ErhBMP-2 Inc. CPC). Lateral ridge augmentation was performed at the buccal aspect of each defect during implant surgery. Bone regeneration and contour maintenance were assessed using micro-CT and histology 3 months postoperatively.

resultsMicro-CT showed that the ErhBMP-2 Inc. CPC group developed substantial mineralised tissue covering the implant surface, with no exposed threads at the implant neck. Trabecular thickness in this group was significantly greater than in the CPC and autologous bone groups. Histology confirmed greater bone marrow formation and horizontal augmentation below the implant shoulder in the ErhBMP-2 Inc. CPC group compared with CPC alone. Collectively, the histological and radiographic findings were consistent with enhanced peri-implant bone regeneration in the ErhBMP-2 Inc. CPC group.

conclusionsErhBMP-2 Inc. CPC enhanced peri-implant bone regeneration than CPC alone. CLINICAL RELEVANCE: Low-dosage ErhBMP-2 incorporated into CPC may offer a more predictable and effective approach for simultaneous lateral ridge augmentation and implant placement by enhancing bone regeneration and maintaining ridge contours.

Indexed as

Alveolar Ridge AugmentationBone CementsBone Morphogenetic Protein 2Calcium PhosphatesTransforming Growth Factor betaAnimalsBone RegenerationDental Implantation, EndosseousDogsHumansMandibleOsseointegrationRecombinant ProteinsX-Ray MicrotomographyBone CementsBone Morphogenetic Protein 2calcium phosphateCalcium Phosphatesrecombinant human bone morphogenetic protein-2Recombinant ProteinsTransforming Growth Factor betaBone Morphogenetic Protein-2Bone regenerationImplantLateral ridge augmentationSlow release

Identifiers

PMID42044606

DOI10.1016/j.identj.2026.109545

PMCPMC13134016

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