ArticleProceedings of the National Academy of Sciences of the United States of America2026
Kinetochore proteins control microtubule dynamics in postmitotic neurons to regulate the formation of dendritic spines.
Guoli Zhao, Aditi Sharma, Jing Tang, Martina Aleman, Xing Liang, Lauren Miner, Jingqi Qi, Wangchu Xiang, Feng Tian, Yves Goldberg and 4 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Aditi Sharma *Univ. Grenoble Alpes, Inserm, U1216, Commissariat à l'énergie atomique et aux énergies alternatives, Grenoble Institut Neurosciences, Grenoble 38000, France.
Jing Tang *F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115.
Martina Aleman *Univ. Grenoble Alpes, Inserm, U1216, Commissariat à l'énergie atomique et aux énergies alternatives, Grenoble Institut Neurosciences, Grenoble 38000, France.ORCID 0009-0004-0456-7458 Xing Liang *Department of Biology, Stanford University, Stanford, CA 94305.
Lauren MinerF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115.
Jingqi QiF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115.
Wangchu XiangF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115.
Feng TianF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115.
Yves GoldbergUniv. Grenoble Alpes, Inserm, U1216, Commissariat à l'énergie atomique et aux énergies alternatives, Grenoble Institut Neurosciences, Grenoble 38000, France.ORCID 0000-0001-7446-8595 Zhigang HeF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115.
Leticia PerisUniv. Grenoble Alpes, Inserm, U1216, Commissariat à l'énergie atomique et aux énergies alternatives, Grenoble Institut Neurosciences, Grenoble 38000, France.ORCID 0000-0002-0668-1252 Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4MViral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MARGARET S LIVINGSTONE · 1998 to 2026
$21.3MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4MSupplement request for Training GrantT32NS007473 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI Elizabeth C. Engle, Thomas L. Schwarz · 1999 to 2026
$6.9MPatterning dendritic branches with environmental and neuronal surface moleculesR01NS082208 · NINDS · STANFORD UNIVERSITY · PI KANG SHEN · 2013 to 2026
$4.1MKinetochore Protein Functions in SynaptogenesisR37NS109211 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI SCHWARZ, THOMAS L. · 2019 to 2025
$4.1MEpigenomic mechanisms regulating RGC survival and axon regenerationR00EY032181 · NEI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Feng Tian · 2024 to 2026
$750kAssociation France Alzheimer (French Alzheimer's Association) SynapCyAlz AAP PFA 2022 R23052CCDyskiTubuline-G7H-IRG24E77 IRGA2024Fondation Recherche Alzheimer C7H-PRI23A64 - FRAlzHHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS082208HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R37NS109211HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) T32NS007473Howard Hughes Medical InstituteNEI NIH HHS P30 EY012196NEI NIH HHS R00 EY032181NICHD NIH HHS P50 HD105351NIDDK NIH HHS P30 DK034854NINDS NIH HHS R01 NS082208NINDS NIH HHS R37 NS109211NINDS NIH HHS T32 NS007473
6 · The paper itselfAbstract
Kinetochore proteins, long studied for their role in cell division, are also required for the proper postmitotic development of hippocampal and cortical neurons. Proteins of the kinetochore complex were present in axons and dendrites of postmitotic iNeurons where they resided, at least in part, at microtubule plus ends. Conditional deletion of mouse Ndc80 or Dsn1 increased the number of dendritic spines. Loss of any of three kinetochore components (Ndc80, Dsn1, or Mis12) increased microtubule plus-end dynamics. Observations of individual microtubules in
Indexed as
Caenorhabditis elegans ProteinsDendritic SpinesKinetochoresMicrotubulesNeuronsAnimalsCaenorhabditis elegansMiceMicrotubule-Associated ProteinsMitosisNuclear ProteinsCaenorhabditis elegans ProteinsMicrotubule-Associated ProteinsNDC-80 protein, C elegansNuclear Proteinsdendritic spineiNeuronkinetochoremicrotubuleNdc80
Identifiers
PMID42044343
PMCPMC13132258
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