ArticlePloS one2026
MedSpectralNet: A lightweight convolutional neural network architecture for multi-modal image classification.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Medical image classification requires models that effectively capture both fine-grained local patterns and global anatomical structures while maintaining computational efficiency for clinical deployment. Although state-of-the-art models such as MedMamba utilize State-Space Models (SSMs) to balance accuracy and efficiency, their sequential operations limit parallelism and increase runtime. To overcome these limitations, we propose MedSpectralNet, a lightweight Convolutional Neural Network (CNN) architecture that approximates self-attention with linear complexity to efficiently extract multi-frequency features. The model introduces a dual-stream feature extractor that processes global and local information in parallel, and a ContextGate block that adaptively fuses multi-scale representations. MedSpectralNet is evaluated across six benchmark datasets from MedMNIST (including BloodMNIST, BreastMNIST, DermaMNIST, PneumoniaMNIST, OrganCMNIST, and OrganSMNIST), MedSpectralNet achieves an average accuracy of 93.7% on OrganCMNIST and 98.0% on BloodMNIST, showing 1-4.3% relative accuracy gains when compared to larger transformer-based models. Importantly, it delivers this performance with only 8.5 million parameters, representing approximately 60% fewer parameters than MedMamba-T, which requires 14.5 million parameters. MedSpectralNet has also achieved high AUC values up to 0.999 across multiple classes, demonstrating state-of-the-art accuracy with substantially reduced computational cost and improved parallelization, which makes MedSpectralNet well-suited for real-time and resource-constrained classification-based medical applications.
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