ArticleCancer medicine2026
Identification of Prognostic Risk Factors in Older Patients With Extensive-Stage Small Cell Lung Cancer.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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15 authors.
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Abstract
Given the limited evidence on prognostic factors specifically for older patients with extensive-stage small cell lung cancer (ES-SCLC), a population with distinct clinical characteristics, this study aimed to validate whether previously reported prognostic indicators retain their predictive value in this vulnerable group. A retrospective analysis was conducted on data from 270 older ES-SCLC patients who received treatment at the Fourth Hospital of Hebei Medical University between December 2016 and June 2024. By the final follow-up date of October 15, 2024, 212 deaths had been recorded. The median progression-free survival (mPFS) was 6.7 months (95% confidence interval [CI] 6.0-7.4), and the median overall survival (mOS) was 13.1 months (95% CI 11.8-14.4). For PFS, univariate and multivariate Cox analyses identified first-line chemotherapy (CT) and old-old (≥ 75 years) as independent adverse prognostic factors. For OS, old-old, a positive smoking history, bone metastasis, and high-lactate dehydrogenase (> 250 U/L) were identified as significant adverse prognostic factors. Notably, high-pro-gastrin-releasing peptide (ProGRP) (> 69.2 pg/mL) was significantly associated with an increased risk of death during the follow-up period beyond 10 months (HR = 1.85, 95% CI 1.05-3.26, p = 0.032); conversely, no significant association was observed within the initial 10 months of follow-up (HR = 0.84, 95% CI 0.44-1.60, p = 0.604). In conclusion, these findings not only corroborate the prognostic value of previously identified risk factors in older patients with ES-SCLC but also demonstrate that the prognostic impact of ProGRP is distinctly time-dependent.
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