Evidence map›Paper›PMID 42043782›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry.

Nicholas R Ray, Jiji Kurup, Ajneesh Kumar, Farid Rajabli, Liyong Wang, Wanying Xu, Fulai Jin, Elanur Yilmaz, Caghan Kizil, Luciana Bertholim-Nasciben and 43 more

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

53 authors.

Nicholas R RayColumbia University Irving Medical Center, New York, New York, USA.
Jiji KurupColumbia University Irving Medical Center, New York, New York, USA.
Ajneesh KumarColumbia University Irving Medical Center, New York, New York, USA.
Farid RajabliUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Liyong WangUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Wanying XuCase Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Fulai JinCase Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Elanur YilmazColumbia University Irving Medical Center, New York, New York, USA.
Caghan KizilColumbia University Irving Medical Center, New York, New York, USA.
Luciana Bertholim-NascibenUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Sofia MouraUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Aura M RamirezUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Olusegun BaiyewuCollege of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Anthony J GriswoldUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Motunrayo CokerCollege of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Kyle M ScottUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Kazeem AkinwandeCollege of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Larry D AdamsUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Samuel DialaCollege of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Patrice G WhiteheadUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Jacob L McCauleyUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Mayowa OgunronbiCollege of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Kara L Hamilton-NelsonUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Albertino DamascenoFaculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Andrew F ZamanUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Susan H BlantonUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Albert AkpaluUniversity of Ghana Medical School, Accra, Ghana.
Michael L CuccaroUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Kolawole WahabDepartment of Medicine, University of Ilorin, Ilorin, Nigeria.
Katalina F McInerneyUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Karen NuytemansUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Reginald ObiakoAhmadu Bello University, Zaria, Kaduna, Nigeria.
Pedro R MenaUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Njideka OkubadejoCollege of Medicine, University of Lagos, Lagos, Nigeria.
Izri M MartinezUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Yared Z ZewdeCollege of Health Sciences of Addis Ababa University, Addis Ababa, Addis Ababa, Ethiopia.
Seid A GugssaCollege of Health Sciences of Addis Ababa University, Addis Ababa, Addis Ababa, Ethiopia.
Fred S SarfoKomfo Anokye Teaching Hospital, Kumasi, Ghana.
Raj KalariaInstitute for Ageing and Health, Newcastle University, Newcastle, UK.
David M NdeteiAfrica Institute of Mental and Brain Health, University of Nairobi, Nairobi, Kenya.
Scott M WilliamsCase Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Allison Caban-HoltWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
ADGC, AfDC
Giuseppe TostoColumbia University Irving Medical Center, New York, New York, USA.
Jonathan L HainesCase Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Rufus O AkinyemiCollege of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Adesola OgunniyiCollege of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
Goldie S ByrdWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
William S BushCase Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Brian W KunkleUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Jeffery M VanceUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Margaret A Pericak-VanceUniversity of Miami Miller School of Medicine, Miami, Florida, USA.
Christiane ReitzColumbia University Irving Medical Center, New York, New York, USA.

Funding

Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)U19AG074865 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Margaret A. Pericak-Vance · 2022 to 2026
$55.3M
Whole Genome Sequencing in Ethnically Diverse Cohorts for the ADSP Follow-Up Study (FUS)U01AG057659 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MAYEUX, RICHARD P, PERICAK-VANCE, MARGARET A. · 2017 to 2021
$34.4M
The National Institute on Aging (NIA) Late Onset of Alzheimer's Disease (LOAD) Family-Based Study (FBS)U24AG056270 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gary Wayne Beecham, TATIANA M. FOROUD · 2017 to 2026
$31.4M
The Origins of Alzheimer Disease in African AmericansR01AG072547 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Rufus Olusola Akinyemi, GOLDIE S. BYRD · 2022 to 2026
$26.1M
Translational and Therapeutics CoreP30AG072959 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI JAGAN AYYAPPAN PILLAI · 2021 to 2026
$23.9M
Characterizing the Genetic Risk for Alzheimer Disease in African and Admixed African-American AncestriesU01AG084545 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GOLDIE S. BYRD, ANTHONY JOHN GRISWOLD · 2024 to 2026
$14.9M
The Alzheimer Disease Sequence Analysis CollaborativeU01AG058654 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI BUSH, WILLIAM S, FARRER, LINDSAY A. · 2018 to 2022
$14.6M
Functional genomic studies in diverse populations to characterize risk loci for Alzheimer DiseaseU01AG072579 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DYKXHOORN, DEREK MICHAEL, GRISWOLD, ANTHONY JOHN · 2021 to 2025
$6.9M
Replication and Extension of ADSP Discoveries in African-AmericansU01AG052410 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BEECHAM, GARY WAYNE, BYRD, GOLDIE S. · 2016 to 2020
$5.2M
Identifying Protective Genetic Variants for APOE4RF1AG059018 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI VANCE, JEFFERY MARVIN · 2018 to 2018
$4.4M
Genetic basis of neuropsychiatric symptoms in Alzheimer's diseaseU01AG079850 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gary Wayne Beecham, Edward D Huey · 2023 to 2026
$3.0M
NIA NIH HHS AG057659NIA NIH HHS AG058654NIA NIH HHS AG072959NIA NIH HHS P30 AG072959NIA NIH HHS R01 AG072547NIA NIH HHS R01AG072547NIA NIH HHS RF1 AG059018NIA NIH HHS RF1AG059018NIA NIH HHS U01 AG052410NIA NIH HHS U01AG052410NIA NIH HHS U01 AG057659NIA NIH HHS U01 AG058654NIA NIH HHS U01 AG072579NIA NIH HHS U01AG072579NIA NIH HHS U01 AG079850NIA NIH HHS U01 AG084545NIA NIH HHS U01AG084545NIA NIH HHS U19 AG074865NIA NIH HHS U19AG074865NIA NIH HHS U24 AG056270
6 · The paper itself

Abstract

introductionNeuropathological studies indicate a strong association between Alzheimer's disease (AD) and stroke, yet the molecular mechanisms underlying this association remain unclear.

methodsLocal genetic correlation analysis was conducted with LAVA (Local Analysis of [co]Variant Annotation) using the results from genome-wide association studies on AD and stroke in individuals of African ancestry. Enhanced Hi-C Capture Analysis (eHiCA) examined chromatin interactions using induced pluripotent stem cell (iPSC) -derived cells from AD brain autopsy samples.

resultsLAVA identified a region shared between AD and stroke on chromosome 18q21.33(r DISCUSSION: This study identified a region on top of PHLPP1 as a locus associated with both AD and stroke. PHLPP1 inhibits protein kinase B, which contributes to both AD and stroke pathophysiology.

Indexed as

Alzheimer DiseaseBlack PeopleNuclear ProteinsPhosphoprotein PhosphatasesStrokeAfrican PeopleAgedFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideNuclear ProteinsPHLPP1 protein, humanPhosphoprotein PhosphatasesAlzheimer's diseasegenetic covariancestroke

Identifiers

PMID42043782
PMCPMC13116102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.