ArticleBulletin of experimental biology and medicine2026
Effects of Amygdalin, 6-Shogaol, and Resveratrol on Inhibition of Differentiation of Monocyte-Derived M4 Macrophages: In Silico and In Vitro Studies.
Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study explores a possible therapy for managing atherosclerosis through macrophage modulation induced by CXCL4 receptor activity. Three herbal compounds potentially blocking the CXCL4 receptor, i.e., amygdalin, 6-shogaol, and resveratrol, were tested in silico and in vitro. In silico analysis revealed the highest binding affinity of amygdalin to the CXCL4 receptor. Flow cytometry of peripheral blood mononuclear cells from 11 healthy subjects showed CD36 expression in groups treated with amygdalin, which attested to macrophage differentiation and maturation. ELISA showed increasing TNF-α production associated with enhanced cell phagocytosis, while MMP7 expression decreased, indicating lower molecular adhesion capability. Thus, amygdalin can potentially prevent M4 macrophage development, which plays a role in atherosclerotic plaque instability, though further validation is needed.
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