Evidence map›Paper›PMID 42043633›Full record

ArticleJournal of autism and developmental disorders2026

Social Adaptation to Change in Peer Behavior Before and After a Pilot Randomized Clinical Trial of a Theatre-Based Intervention for Adults With Autism.

Rachael A Muscatello, Mark E Klemencic, Rachel Calvosa, Blythe A Corbett

Registry-linked trialAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04349644 (Enhancing Social Competence in Adults With Autism Spectrum Disorder), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04349644 nacompletednot on this map

Enhancing Social Competence in Adults With Autism Spectrum Disorder: A Pilot RCT

TypeinterventionalSponsorVanderbilt University Medical CenterRan2020 to 2025Enrolled72ConditionsAutism Spectrum DisorderArmsSENSE Theatre
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rachael A MuscatelloDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-9862-1686
Mark E KlemencicDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-8722-6808
Rachel CalvosaVanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0009-0000-8636-0565
Blythe A CorbettDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. blythe.corbett@vumc.org.ORCID http://orcid.org/0000-0003-2165-8015

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Enhancing Social Competence in Adults with Autism Spectrum Disorder: A Pilot RCTR33MH120149 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CORBETT, BLYTHE ANNE · 2020 to 2022
$1.4M
NICHD NIH HHS P50 HD103537NIMH NIH HHS MH120149NIMH NIH HHS R33 MH120149
6 · The paper itself

Abstract

purposePsychosocial interventions have been designed for autism spectrum disorder (ASD), but most focus on youth. Adaptation to social context was examined before and after a pilot randomized control trial of a theatre-based intervention for autistic adults. Depressive symptom impact on treatment outcomes was also investigated.

methodsSixty-one adults, ages 18–40 years with ASD, randomized to an experimental (EXP, n = 29) or waitlist control (WLC, n = 32) group, participated in a social interaction paradigm (Contextual Assessment of Social Skills; CASS) pre- and post-intervention. Depressive symptoms (Beck Depression Inventory) were examined as a predictor of behavioral change on the CASS post-intervention.

resultsBefore the intervention, adults in the EXP and WLC group had significant behavior adaptation between the Interested and Bored CASS conditions (corrected p < .01). Analysis of covariance of a Social Adaptation Index, controlling for pretest scores, was not significant for group (EXP vs WLC) (F(1,36) = 0.398, p = .532, ηp2 = 0.011) or sex (F(1,36) = 0.160, p = .691, ηp2 = 0.004). Depression and perception of peer behavior were correlated at pretest (r = -.277, p = .032), but pre-intervention depressive symptoms were not predictive of post-intervention behavior, nor was there a depression-by-group interaction (p > .05).

conclusionsThe intervention did not significantly impact social adaptation as measured by behavioral changes across social interaction contexts; however, autistic adults were already able to differentiate social conditions prior to the intervention. The CASS may not be optimal for broadly measuring treatment effects in adults. Paradigms are needed to more comprehensively measure behaviors that may be enhanced following social skills interventions.

trial registrationThe trial was pre-registered with ClinicalTrials.gov (Identifier: NCT04349644).

Indexed as

AutismDepressionInterventionSocial adaptationSocial behavior

Identifiers

PMID42043633
PMCPMC13154100

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