ArticleMammalian genome : official journal of the International Mammalian Genome Society2026
PI3KCD gene expression and its role in diabetic intervertebral disc degeneration running title: PI3KCD gene crucial for diabetic IDH.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diabetes mellitus (DM) affects 8% of the population and impacts various connective tissues. Obesity, type 2 diabetes mellitus (T2DM), and their metabolic effects are increasingly linked to intervertebral disc degeneration (IVDD). Diabetic patients develop disc degeneration at younger ages and with higher frequency than non-diabetics. To investigate the role of PI3KCD in high glucose-induced IVDD and explore potential therapeutic approaches. The study examined PI3KCD expression in nucleus pulposus (NP) cells under high glucose conditions and investigated its regulatory mechanism through the PI3K/AKT pathway. The effects of PI3KCD agonist 740Y-P were also evaluated. High glucose conditions significantly decreased PI3KCD expression in NP cells. PI3KCD knockdown accelerated high glucose-induced NP cell death. The study revealed PI3KCD regulates NP cells via the PI3K/AKT pathway, with high glucose potentially reducing PI3KCD expression through increased cellular oxidative stress. The PI3KCD agonist 740Y-P demonstrated potential in partially reversing diabetes-induced IVDD, presenting a promising therapeutic approach for diabetic IVDD treatment.
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