Evidence map›Paper›PMID 42043560›Full record

ReviewIntensive care medicine2026

How outcomes are defined in randomized controlled trials of acute kidney injury: a scoping review.

Nathalia Mavignier, Gobinder Pandher, Maxime Goldstein, Natalja L Stanski, Dana Y Fuhrman, Ayse Akcan Arikan, Emily See, Peggy Tahir, Javier A Neyra, Sean M Bagshaw and 2 more

Abstract readScoping ReviewReview
PubMed Publisher
In one paragraph

Review in Intensive care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nathalia Mavignier *Department of Anesthesia and Perioperative Care, Division of Critical Care Medicine, University of California, San Francisco (UCSF), San Francisco, USA.
Gobinder Pandher *Department of Anesthesia and Perioperative Care, Division of Critical Care Medicine, University of California, San Francisco (UCSF), San Francisco, USA.
Maxime GoldsteinDepartment of Intensive Care, Centre Hospitalier Universitaire de Lille, Lille, France.
Natalja L StanskiDivision of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.
Dana Y FuhrmanDivision of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.
Ayse Akcan ArikanDepartment of Pediatrics, Renal Division, Baylor College of Medicine, Texas Children's Hospital, Houston, USA.
Emily SeeDepartments of Intensive Care and Nephrology, Royal Melbourne Hospital, Melbourne, Australia.
Peggy TahirUCSF Library, University of California San Francisco, San Francisco, USA.
Javier A NeyraDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA.
Sean M BagshawDepartment of Critical Care Medicine, University of Alberta and Alberta Health Services, Edmonton, Canada.
Matthieu Legrand *Department of Anesthesia and Perioperative Care, Division of Critical Care Medicine, University of California, San Francisco (UCSF), San Francisco, USA. matthieu.m.legrand@gmail.com.ORCID http://orcid.org/0000-0001-9788-5316
Bruno Garcia *Department of Intensive Care, Centre Hospitalier Universitaire de Lille, Lille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionResearch on acute kidney injury (AKI) is hindered by heterogeneous definitions, measurements, and follow-up periods, which limit comparability across randomized controlled trials (RCTs) and the translation of findings into evidence-based practice. This review aimed to describe outcomes reported in RCTs of AKI prevention and treatment.

methodsThis scoping review followed PRISMA-ScR guidance. PubMed, Embase, Web of Science, and Cochrane CENTRAL were searched for RCTs published between January 2014 and April 2024. Eligible studies included adults or children with AKI or at risk for AKI. Outcomes were categorized using the COMET taxonomy according to core area, core domain, specific domain, measurement method, and timing.

resultsAmong 3921 abstracts screened, 251 RCTs were included. Prevention trials represented 197/251 (78.5%). Most outcomes belonged to the Physiological/Clinical Core Area (194/197, 98.5%), in the Renal outcomes Core Domain (186/197, 94%). Renal function (162/197, 82%) and renal damage (15/197, 7.5%) were the most frequent domains. Measurements relied mainly on serum creatinine, alone (130/162, 80%) or combined with urine output (25/162, 15%), assessed between 48-72 h (65%) and 7 days (22%). Outcomes in therapeutic RCTs (54/251, 21.5%) belonged to the Physiological/Clinical (37/54, 69%) and Mortality/Survival (14/54, 26%) Core Areas. Renal outcomes (33/54, 61%) included renal function (9/54, 17%), renal recovery (10/54, 19%), and use of RRT (3/54, 6%). Measurements included serum creatinine (16/54, 30%), mortality (14/54, 26%) and estimated glomerular filtration rate (eGFR) (3/54, 6%), assessed between 7 and 90 days.

conclusionOutcome reporting is heterogeneous, highlighting the need for a standardized core outcome set.

Indexed as

Acute Kidney InjuryOutcome Assessment, Health CareRandomized Controlled Trials as TopicHumansAcute kidney injuryCOMETCore outcome setEndpoints

Identifiers

PMID42043560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.