ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2026
Diagnostic value of hypoxia-inducible factor 1 alpha and adrenomedullin in acute mesenteric ischemia.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study aims to evaluate the diagnostic significance of adrenomedullin and hypoxia-inducible factor 1 alpha (HIF1-alpha) levels in an animal model of acute mesenteric ischemia. MATERIALS AND
methodsIn our study, a total of 21 male New Zealand rabbits were used, and the animals were divided into three groups for the study. Blood samples were taken for adrenomedullin and HIF1-alpha levels at 0, 1, 3, and 6 h from the control, sham, ischemia groups.
resultsHIF levels of the ischemia group at the 3rd and 6th hours were statistically significantly higher than those in the sham (p = 0.002, p < 0.001, respectively) and control groups (p = 0.002, p < 0.001, respectively). Adrenomedullin levels of the ischemia group at the 1st, 3rd, and 6th hours were statistically significantly higher than those in the sham (p = 0.004, p < 0.001, p < 0.001, respectively) and control groups (p < 0.001, p < 0.001, p < 0.001 respectively).
conclusionIn this experimental model of acute mesenteric ischemia, hypoxia-inducible factor-1 alpha and adrenomedullin levels were significantly higher in the ischemia group compared with the control and sham groups. Adrenomedullin demonstrated an earlier increase, while hypoxia-inducible factor-1 alpha increased significantly at later time points. These biomarkers may provide supportive diagnostic value when interpreted alongside clinical and imaging findings; however, further clinical studies are required to confirm their role in the early diagnosis of acute mesenteric ischemia.
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