ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2026
Malignancy risk and management outcomes in adult intussusception: a single-institution retrospective study.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeAdult intussusception is rare and frequently caused by a pathological lead point, including malignancy. We assessed malignancy rates by CT-based anatomical subtype/location, identified predictors of malignancy, and summarized management outcomes to support risk-stratified decision-making in the emergency setting.
methodsWe conducted a single-institution retrospective study at Tri-Service General Hospital (Taipei, Taiwan), including consecutive adults with CT-diagnosed intussusception from January 2015 to August 2024. We collected demographics, symptoms, hemoglobin, CT-based type/location, management, and histopathology. Malignancy was defined by index-admission pathology (malignant vs. benign). Anemia was defined as hemoglobin < 13 g/dL in men or < 12 g/dL in women. Predictors of malignancy were evaluated using univariable and multivariable logistic regression. Primary analyses included pathology-confirmed cases; sensitivity analyses additionally included presumed benign cases.
resultsForty-seven patients were identified; 38 had pathology-confirmed outcomes. In the primary cohort (n = 38), 18 (47.4%) were malignant. Lower hemoglobin was associated with malignancy (OR per 1 g/dL increase, 0.709; 95% CI, 0.529–0.950; p = 0.021), and anemia strongly predicted malignancy (OR, 11.667; 95% CI, 2.438–55.830; p = 0.002). In multivariable analysis adjusting for age and colonic location, anemia remained independently associated with malignancy (adjusted OR, 13.540; 95% CI, 2.350–78.000; p = 0.004). Findings were consistent in sensitivity analyses including nine presumed benign cases (symptom resolution within 72 h without intervention and no recurrence for ≥ 2 years).
conclusionMalignancy was common among symptomatic adults with intussusception in this single-institution cohort. Anemia was a strong independent predictor of malignancy and may complement CT-based evaluation for risk stratification and operative planning in the emergency setting.
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