ArticleChemMedChem2026
Allium-Derived Compounds Against Multidrug-Resistant Bacteria: Antibacterial Activity and Synergistic Effects.
Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
BACKGROUND AND
objectivesAntibiotic resistance is a major global health challenge, driven by misuse in medicine and agriculture and the scarcity of new drugs. Allium-derived organosulfur molecules have shown antimicrobial and synergistic effects with antibiotics. This study aimed to evaluate the in vitro antibacterial activity of four Allium-derived compounds and their potential synergy with clinical antibiotics against multidrug-resistant bacteria.
methodsA total of 330 multidrug-resistant clinical isolates were analyzed, including Gram-positive cocci and Gram-negative bacilli. Antibacterial activity of propyl-propane-thiosulfinate, propyl-propane-thiosulfonate (PTSO), butyl-butane-thiosulfinate, and butyl-butane-thiosulfonate was determined by broth microdilution. Synergy with conventional antibiotics was assessed in 24 representative isolates using the checkerboard method, with interactions classified by the fractional inhibitory concentration index.
resultsPTSO exhibited the highest activity, with MIC
conclusionPTSO demonstrated the most significant activity against multidrug-resistant Gram-positive bacteria, with limited impact on Gram-negative strains, and partial synergy with aminoglycosides suggests a potential role for combination therapy.
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