ArticleProtein science : a publication of the Protein Society2026
Multivalent recognition of ferritin by full-length NCOA4 enables robust ferritinophagy.
Ayush K Srivastava, Genki Terashi, Rosa Viner, Audrey Kishishita, Arun P Wiita, Anitha Rajendran, Yeonni Zoo, Georgia C Papaefthymiou, Daisuke Kihara, Fadi Bou-Abdallah
Abstract read
In one paragraphArticle in Protein science : a publication of the Protein Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Ayush K SrivastavaDepartment of Chemistry, State University of New York, Potsdam, New York, USA.
Genki TerashiDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Rosa VinerThermo Fisher Scientific, San Jose, California, USA.
Audrey KishishitaDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
Anitha RajendranDepartment of Chemistry, State University of New York, Potsdam, New York, USA.
Yeonni ZooDepartment of Physics, Villanova University, Villanova, Pennsylvania, USA.
Georgia C PapaefthymiouDepartment of Physics, Villanova University, Villanova, Pennsylvania, USA.
Daisuke KiharaDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Funding
Building protein structure models for intermediate resolution cryo-electron microscopy mapsR01GM133840 · NIGMS · PURDUE UNIVERSITY · PI KIHARA, DAISUKE · 2020 to 2023
$1.6MData-driven biomolecular structure modeling for cryo-EM mapsR35GM158267 · NIGMS · PURDUE UNIVERSITY · PI Daisuke Kihara · 2025 to 2026
$791kIntroducing a novel computational framework for B-cell epitope prediction based on immune-induced selection signaturesR21AI187928 · NIAID · PURDUE UNIVERSITY · PI HE, QIXIN · 2025 to 2025
$406kNational Science Foundation 2231900National Science Foundation DBI2146026National Science Foundation DBI2422620National Science Foundation DBI2433490National Science Foundation IIS2211598National Science Foundation MRI 1531991NIAID NIH HHS R21 AI187928NIAID NIH HHS R21AI187928NIGMS NIH HHS R01 GM133840NIGMS NIH HHS R01GM133840NIGMS NIH HHS R35 GM158267NIGMS NIH HHS R35GM158267
6 · The paper itselfAbstract
Ferritinophagy is a central pathway in cellular iron homeostasis, yet the molecular basis by which the selective autophagy receptor NCOA4 recognizes and engages ferritin remains poorly defined, largely due to the long-standing inability of working with a soluble form of the full-length human NCOA4 (NCOA4
Indexed as
AutophagyFerritinsNuclear Receptor CoactivatorsHumansModels, MolecularProtein BindingFerritinsNCOA4 protein, humanNuclear Receptor Coactivatorsferritinferritinophagyintrinsically disordered protein (IDP)multivalent bindingNCOA4
Identifiers
PMID42043318
PMCPMC13114776
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