Evidence map›Paper›PMID 42043313›Full record

ReviewCancer biology & medicine2026

Design principles of nanomaterials for cancer immunotherapy: a mechanistic framework across the cancer immunity cycle.

Yating Bai, Zhihao Lan, Nana Feng, Zhanzhan Zhang, Yang Liu

Abstract readReview
In one paragraph

Review in Cancer biology & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yating BaiState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials Ministry of Education, College of Chemistry, Frontiers Science Center for New Organic Matter, Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin 300071, China.
Zhihao LanState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials Ministry of Education, College of Chemistry, Frontiers Science Center for New Organic Matter, Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin 300071, China.
Nana FengState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials Ministry of Education, College of Chemistry, Frontiers Science Center for New Organic Matter, Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin 300071, China.
Zhanzhan ZhangState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials Ministry of Education, College of Chemistry, Frontiers Science Center for New Organic Matter, Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin 300071, China.ORCID 0009-0004-0659-0125
Yang LiuState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials Ministry of Education, College of Chemistry, Frontiers Science Center for New Organic Matter, Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin 300071, China.ORCID 0000-0001-5752-5180

Funding

Academy for Advanced Interdisciplinary Studies, Nankai University (AAIS, NKU), and the Frontiers Science Center for New Organic Matter, Nankai University 63181206Key Projects of Tianjin Science and Technology 24ZXZSSS00150National Natural Science Foundation of China 22077073National Natural Science Foundation of China 52203172National Natural Science Foundation of China 52373143National Natural Science Foundation of China 52525310Tianjin Science Foundation for Distinguished Young Researchers 24JCJQJC00290
6 · The paper itself

Abstract

Cancer immunotherapy has revolutionized oncology by harnessing the immune system to eliminate malignant cells, yet its efficacy remains constrained by insufficient antigen presentation, limited T cell infiltration, and the immunosuppressive tumor microenvironment (TME). Nanotechnology provides strategies to address these barriers by enabling the precise delivery of antigens, adjuvants, cytokines, checkpoint inhibitors, and nucleic acids, while protecting labile cargos and allowing for controlled release. Beyond serving as carriers, nanoparticles can regulate antitumor immunity by enhancing antigen presentation, promoting T cell priming and infiltration, and remodeling the TME. This review outlines key physiological barriers to

Indexed as

ImmunotherapyNanostructuresNeoplasmsAnimalsHumansNanoparticlesT-LymphocytesTumor MicroenvironmentCancer immunotherapyimmune modulationnanoparticlesT cell activationtumor microenvironment

Identifiers

PMID42043313
PMCPMC13115413

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.