ReviewJournal of agricultural and food chemistry2026
Structural Evolution and Immunomodulatory Versatility of Fungal Immunomodulatory Proteins: Insights into Mechanisms and Bioproduction Strategies.
Review in Journal of agricultural and food chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal immunomodulatory proteins (FIPs) are low-molecular-weight proteins from macrofungi that share the potential to modulate immune responses. Structurally, they fall into five subgroups, with the Fve-type and Cerato-type being the most representative. Originally, these proteins evolved in fungi for mycoparasitism and defense; their immunomodulatory, antitumor, anti-inflammatory, and hepatoprotective effects validated in human cells and animal models are surprisingly beneficial. Post-translational modifications and specific oligomeric states regulate the FIP functionality. These structural features critically govern receptor engagement and downstream signaling, whereby FIPs orchestrate immune responses via Toll-like receptor/NF-κB modulation and exert antitumor effects through EGF receptor/Akt interference. Recent advances in genomic mining and bioinformatics have accelerated novel FIP discovery, while scalable production is now achievable through optimized heterologous expression systems incorporating solubility-enhancing tags, promoter engineering, endotoxin removal, and tailored fermentation. This review examines the structure-activity relationships, mechanism-driven bioactivities, and bioproduction platforms of FIPs, highlighting their potential in biopharmaceutical and functional food applications.
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