Evidence map›Paper›PMID 42043301›Full record

ArticleAcademic emergency medicine : official journal of the Society for Academic Emergency Medicine2026

Medication Management of Early Pregnancy Loss in an Urban Texas Emergency Department.

Lindsay Cline, Emilie Sandfeld, Haley Brunkal, Madeline Fischer, Allison Gilbert, Lauren Fine, Emily E Ager

Abstract read
In one paragraph

Article in Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Medication Management of Early Pregnancy Loss in an Urban Texas Emergency Department.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lindsay ClineTexas A&M University College of Medicine, Bryan, Texas, USA.
Emilie SandfeldTexas A&M University College of Medicine, Bryan, Texas, USA.
Haley BrunkalTexas A&M University College of Medicine, Bryan, Texas, USA.
Madeline FischerIndependent consultant, Philadelphia, PA.
Allison GilbertTexas A&M University College of Medicine, Bryan, Texas, USA.
Lauren FineTexas A&M University College of Medicine, Bryan, Texas, USA.
Emily E AgerDepartment of Emergency Medicine, University of California San Francisco, San Francisco, California, USA.

Funding

University of California San Francisco National Clinician Scholars Program
6 · The paper itself

Abstract

backgroundAmong patients with early pregnancy loss (EPL) without medication complications or need for urgent surgical evacuation, treatment should largely be guided by patient preference. However, evidence describing medication management for EPL in the emergency department (ED) setting is limited. We examine the occurrence of medication management of EPL with misoprostol in an urban Texas ED, describe associated clinical outcomes, and identify patient and clinical factors associated with offering this treatment.

methodsThis was a retrospective study of patients with confirmed EPL at a single urban academic ED in Texas from November 1, 2022, to May 31, 2024. Data were collected via relevant EHR review. Eligible patients were identified via ICD-10 codes and reviewed using a structured abstraction tool. We identified patients who received expectant or medication management with misoprostol and reported clinical outcomes using descriptive statistics. An exploratory multivariable logistic regression was used to identify characteristics predictive of patients being offered misoprostol.

resultsDuring the study period, 181 patients met our inclusion criteria. Most patients (n = 154; 85.1%) received expectant management. Misoprostol was offered to 44 patients (24%); 27 patients (15.0%) received the medication, all of whom had an OB consult. Seven-day return ED visits were low in both the expectant (n = 18; 11.5%) and medication (n = 2; 7.4%) management groups. Of the 18 patients managed expectantly with a 7-day return ED visit, six received misoprostol during the second visit. OB consultation strongly predicted patients being offered misoprostol (aOR 15.1; 95% CI 4.8-47.61).

conclusionMedication management was rarely provided to ED patients with confirmed EPL; OB was consulted for all patients who received misoprostol. Return ED visits were rare among patients managed expectantly and with misoprostol. Several patients received misoprostol during a return ED visit, which may suggest a missed opportunity for medication treatment of EPL during initial ED presentation.

Indexed as

Abortifacient Agents, NonsteroidalAbortion, SpontaneousEmergency Service, HospitalMisoprostolAdultFemaleHumansPregnancyRetrospective StudiesTexasAbortifacient Agents, NonsteroidalMisoprostolearly pregnancy lossmiscarriagereproductive healthspontaneous abortion

Identifiers

PMID42043301
PMCPMC13116052

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.