Evidence map›Paper›PMID 42043297›Full record

ArticleeLife2026

AFD thermosensory neurons mediate tactile-dependent locomotion modulation in

Manuel Rosero, Jihong Bai

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Manuel RoseroBasic Sciences Division, Fred Hutchinson Cancer Center, Seattle, United States.ORCID https://orcid.org/0000-0001-8950-7251
Jihong BaiBasic Sciences Division, Fred Hutchinson Cancer Center, Seattle, United States.ORCID https://orcid.org/0000-0001-6773-2175

Funding

Training in Cellular & Molecular BiologyT32GM136534 · NIGMS · UNIVERSITY OF WASHINGTON · PI Andrew Atwell Oberst, LARRY S ZWEIFEL · 2021 to 2026
$5.8M
Molecular Interplay of Endocytic ProteinsR01NS115974 · NINDS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Jihong Bai · 2020 to 2026
$4.2M
Signaling Pathways that Modulate Neuronal ActivityR01NS109476 · NINDS · UNIVERSITY OF WASHINGTON · PI Michael Ailion, Jihong Bai · 2020 to 2026
$2.5M
In vivo mechanisms for integration of contextual informationF31NS129545 · NINDS · FRED HUTCHINSON CANCER CENTER · PI ROSERO, MANUEL · 2023 to 2024
$87k
NIGMS NIH HHS T32GM136534NINDS NIH HHS F31NS129545NINDS NIH HHS R01NS109476NINDS NIH HHS R01NS115974
6 · The paper itself

Abstract

Sensory neurons drive animal behaviors by detecting environmental stimuli and relaying information to downstream circuits. Beyond their primary roles in sensing, these neurons often form additional synaptic connections outside their main sensory modality, suggesting broader contributions to behavior modulation. Here, we uncover an unexpected role for the thermosensory neuron AFD in coupling tactile experience to locomotion modulation in

Indexed as

Caenorhabditis elegansLocomotionSensory Receptor CellsThermosensingTouchAnimalsCaenorhabditis elegans ProteinsCyclic GMPSignal TransductionTaxis ResponseCaenorhabditis elegans ProteinsCyclic GMPbehavioral plasticityC. eleganscGMP signalingcyclic nucleotide-gated channelelectrical synapseguanylyl cyclaseneuroscience

Identifiers

PMID42043297
PMCPMC13120819

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.