ArticleViruses2026
LL-37 Inhibits EV71 Infection by Upregulating STAC via the EGFR-ERK Signaling Pathway.
Jiaqi Zhang, Hanlin Zhang, Yi Chen, Hanfei Liu, Shuhuang Peng, Jiwei Zhao, Zhe Luan, Yujian Zhang, Meng Dong, Wanzhu Jin and 1 more
Abstract read
In one paragraphArticle in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Jiaqi ZhangMedical School of Chinese People's Liberation Army, Beijing 100853, China.
Hanlin ZhangState Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Hanfei LiuMedical School of Chinese People's Liberation Army, Beijing 100853, China.
Shuhuang PengMedical School of Chinese People's Liberation Army, Beijing 100853, China.
Jiwei ZhaoMedical School of Chinese People's Liberation Army, Beijing 100853, China.
Zhe LuanDepartment of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.ORCID 0000-0002-0003-1195 Yujian ZhangState Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0009-0001-1010-9195 Meng DongState Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-8523-8602 Wanzhu JinState Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Gang SunMedical School of Chinese People's Liberation Army, Beijing 100853, China.
Funding
China Postdoctoral Science Foundation 2023T160641National Key Research and Development Program of China 2023YFF1305404National Natural Science Foundation of China 32170898
6 · The paper itselfAbstract
LL-37, a 37-amino acid human-derived antimicrobial peptide, was shown in our earlier clinical study to shorten the negative conversion time of the Omicron BA.5.1.3 variant of SARS-CoV-2. In this work, we investigated the broad mechanism of LL-37 by examining its inhibitory effect on non-enveloped virus
Indexed as
Antimicrobial Cationic PeptidesAntiviral AgentsEnterovirus A, HumanEnterovirus InfectionsMAP Kinase Signaling SystemAnimalsCathelicidinsCell LineErbB ReceptorsHumansSignal TransductionUp-RegulationVirus ReplicationAntimicrobial Cationic PeptidesAntiviral AgentsCathelicidinsEGFR protein, humanErbB ReceptorscathelicidinEV71host defense peptideSTAC
Identifiers
PMID42043231
PMCPMC13120454
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