ArticleMembranes2026
Enhanced Properties of Collagen Nanofiber Scaffolds via Chitosan/Polypyrrole/Glutaraldehyde Double-Crosslinking.
Article in Membranes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
To enhance the functionality of collagen (Coll)-based scaffolds, we developed a double-crosslinking strategy incorporating an electroconductive chitosan (Ch) and polypyrrole (Ppy) composite. Successful pre-crosslinking of Ch and Ppy was achieved using glutaraldehyde (GTA) at 100 µM. This facilitated imine linkage formation, confirmed by FTIR, enabling synergistic integration with Coll and successful nanofiber scaffold fabrication via electrospinning. While increasing the Ch-Ppy-GTA ratio affected the spinning process and higher GTA concentrations compromised fiber homogeneity, all other measured properties generally improved with increasing ratios. Crucially, this methodology allowed the membranes to maintain their morphology and significantly extended their degradation profile up to 20-30 days in PBS medium at 37 °C. Furthermore, the scaffolds exhibited electroactivity characterized by pseudocapacitance in the presence of Na
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