Effect of High-Salt Diet on Memory and Behavior in Mice Expressing Human Apolipoprotein Epsilon-4 (APOE4) Allele.

Riad Abdulmoniem, Mia Rivers, Gabriel Carter, Syed J Khundmiri, Jahn N O'Neil

Abstract read

In one paragraph

Article in NeuroSci, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Riad AbdulmoniemDepartment of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA.

Mia RiversDepartment of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA.ORCID 0009-0006-5394-9852

Gabriel CarterDepartment of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA.

Syed J KhundmiriDepartment of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA.

Jahn N O'NeilDepartment of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA.

Funding

Howard University College of Medicine Bridge GrantHoward University College of Medicine Center of Excellence Junior Faculty Award

6 · The paper itself

Abstract

Apolipoprotein epsilon (APOE) is a small molecular protein that regulates lipid and lipoprotein homeostasis. Several reports demonstrated that apolipoprotein epsilon-4 allele (APOE4) expression significantly increases the genetic risk of Alzheimer's disease (AD) and chronic kidney disease. However, there is inconsistent evidence of the association of AD with dietary habits, especially salt intake. Therefore, we hypothesized that high dietary salt intake would exacerbate cognitive decline in mice expressing the human APOE4 allele. We used human APOE (APOE4 and APOE3) knock-in mice to test this hypothesis. Young adult male and female mice aged 5-7 months old (

Indexed as

APOE3APOE4behaviordietary saltmemory

Identifiers

PMID42042624

DOI10.3390/neurosci7020043

PMCPMC13119126

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.