Evidence map›Paper›PMID 42042609›Full record

ArticleMethods and protocols2026

Effect of Loading Strategy on Methylene Blue Encapsulation in Ethosomes: A Comparative Study of Aqueous and Ethanol Phases.

Dmitry Yakovlev, Kanamat Efendiev, Polina Alekseeva, Vladimir Makarov, Kirill Linkov, Anna Lukianova, Vladimir Oleinikov, Victor Loschenov

Abstract read
In one paragraph

Article in Methods and protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dmitry YakovlevProkhorov General Physics Institute, Russian Academy of Science, 119991 Moscow, Russia.
Kanamat EfendievProkhorov General Physics Institute, Russian Academy of Science, 119991 Moscow, Russia.ORCID 0000-0002-5864-1172
Polina AlekseevaProkhorov General Physics Institute, Russian Academy of Science, 119991 Moscow, Russia.ORCID 0000-0003-2716-4606
Vladimir MakarovProkhorov General Physics Institute, Russian Academy of Science, 119991 Moscow, Russia.ORCID 0000-0001-9622-1550
Kirill LinkovProkhorov General Physics Institute, Russian Academy of Science, 119991 Moscow, Russia.ORCID 0000-0003-0218-5443
Anna LukianovaDepartment of Laser Micro-, Nano-, and Biotechnology, Institute of Engineering Physics for Biomedicine, National Research Nuclear University "MEPhI", 115409 Moscow, Russia.
Vladimir OleinikovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, 117997 Moscow, Russia.ORCID 0000-0003-4623-4913
Victor LoschenovProkhorov General Physics Institute, Russian Academy of Science, 119991 Moscow, Russia.ORCID 0000-0002-0507-2367

Funding

Russian Science Foundation 25-75-10156
6 · The paper itself

Abstract

This study presents a comparative analysis of the effect of methylene blue (MB) loading strategy on the physicochemical and colloidal properties of ethosomes prepared by the cold method. Two synthesis protocols differing in the phase of introduction of the cationic hydrophilic dye were investigated: a classical approach with MB loading into the aqueous phase and an alternative approach involving MB incorporation into the ethanolic lipid phase. It is shown that the loading strategy is a critical technological factor determining vesicle size, encapsulation efficiency, loading capacity, and electrokinetic properties of the systems. The alternative method results in the formation of smaller ethosomes (R

Indexed as

colloidal stabilityencapsulation efficiencyethosomesloading strategymethylene bluephotodynamic therapytransdermal deliveryvesicular drug delivery

Identifiers

PMID42042609
PMCPMC13119365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.