Evidence map›Paper›PMID 42042480›Full record

ReviewInsects2026

Insect SVWC Proteins: A Diverse Cytokine-like Family Orchestrating Multilayered Antiviral and Antibacterial Immunity.

Yangyang Chen, Gaoying Xu, Jingao Wang, Cong Zhang, Aliyu Yusuf Abubakar, Hengchuan Xia

Abstract readReview
In one paragraph

Review in Insects, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yangyang ChenSchool of Life Sciences, Jiangsu University, Zhenjiang 212013, China.
Gaoying XuSchool of Life Sciences, Jiangsu University, Zhenjiang 212013, China.
Jingao WangSchool of Life Sciences, Jiangsu University, Zhenjiang 212013, China.
Cong ZhangSchool of Life Sciences, Jiangsu University, Zhenjiang 212013, China.ORCID 0009-0006-3594-170X
Aliyu Yusuf AbubakarSchool of Life Sciences, Jiangsu University, Zhenjiang 212013, China.
Hengchuan XiaSchool of Life Sciences, Jiangsu University, Zhenjiang 212013, China.ORCID 0000-0002-5701-6092

Funding

National Natural Science Foundation of China 31372259Natural Science Foundation for Universities of Jiangsu Province 10KJB180001Start-Up Research Funding of Jiangsu University for Distinguished Scholars 09JDG005
6 · The paper itself

Abstract

The single von Willebrand factor C (SVWC) domain-containing protein family represents a crucial class of immune molecules recently identified in insects and crustaceans. Initially regarded as functional analogs of vertebrate interferons (IFNs) due to their virus-induced expression and activation of the Janus kinase-signal transducer and activator of the transcription (JAK-STAT) pathway, recent studies have revealed that SVWC proteins possess far more complex functions. Many SVWC members are themselves a novel class of pattern recognition receptors (PRRs) that can directly bind to viruses and bacteria. Importantly, SVWCs are not a single entity but a highly diverse family-multiple subtypes exist in

Indexed as

cytokine diversityDicer-2functional specializationinsect immunityJAK/STAT pathwaypattern recognition receptorSVWCVago

Identifiers

PMID42042480
PMCPMC13115929

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.