Design and Development of Teixobactin Analog-Loaded Magnetic Nanocomposites for Biofilm Destruction and Pathogen Elimination.

Huaxiang Lei, Ye Liang, Xuechen Li, Xiaojing Huang, Chengfei Zhang, Ting Zou

Abstract read

In one paragraph

Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huaxiang LeiRestorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.

Ye LiangRestorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.

Xuechen LiDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, China.

Xiaojing HuangFujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province, School and Hospital of Stomatology, Fujian Medical University, Fuzhou 350001, China.ORCID 0000-0003-2040-8532

Chengfei ZhangRestorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.

Ting ZouShenzhen Clinical College of Stomatology, School of Stomatology & Shenzhen Stomatology Hospital (Pingshan), Southern Medical University, Shenzhen 518118, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although teixobactin, a promising cyclic undecadepsipeptide, exhibits efficacy against Gram-positive bacteria due to its novel mode of action and low potential for resistance, its clinical application is limited by two key shortcomings: ineffectiveness against Gram-negative bacteria and poor penetration of the protective extracellular polymeric substance (EPS) in biofilms. This renders it unsuitable for targeting the polymicrobial biofilms, which are the cause of periodontitis and peri-implantitis. We designed a modified teixobactin analog by integrating rhamnolipid, Ag@Fe

Indexed as

biofilm eradicationEPSL-Chg10-teixobactinmagnetic nanoparticlesrhamnolipid

Identifiers

PMID42042296

DOI10.3390/jfb17040189

PMCPMC13118049

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.