Evidence map›Paper›PMID 42042205›Full record

ArticleMarine drugs2026

Phaseolorin J Alleviates Cellular Inflammation and Oxidative Stress by Inhibiting NLRP3 Inflammasome Expression via the Nrf2/HO-1 Pathway.

Yuanjie Chen, Ting Feng, Xiaojing Li, Jing Xu, Juren Cen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuanjie ChenHainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, School of Life and Health Sciences, Hainan University, Haikou 570228, China.
Ting FengCollaborative Innovation Center of Ecological Civilization, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, China.
Xiaojing LiCollaborative Innovation Center of Ecological Civilization, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, China.
Jing XuCollaborative Innovation Center of Ecological Civilization, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, China.ORCID 0000-0002-6201-5318
Juren CenHainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, School of Life and Health Sciences, Hainan University, Haikou 570228, China.

Funding

Collaborative Innovation Center Foundation of Hainan University XTCX2022STB01National Natural Science Foundation of China 82160675
6 · The paper itself

Abstract

Phaseolorin J (TT-55), a chromone compound isolated and purified from the fermentation products of Phomopsis asparagi DHS-48, is an endophytic fungus obtained from mangrove forests. Preliminary experimental studies have revealed its potent antioxidant and anti-inflammatory activities, though its mechanism of action remains unclear. In this study, we aimed to investigate the molecular mechanisms underlying the antioxidant and anti-inflammatory effects of TT-55, following initial evidence of its potency, by employing an LPS-induced RAW264.7 macrophage model in vitro. The results revealed that in the LPS-induced inflammatory model of RAW264.7 cells, the TT-55 dose dependently inhibited the expression of LPS-induced inflammatory cytokines (TNF-α, IL-18, IL-1β, IL-6) and the production of oxidative stress markers (reactive oxygen species, SOD, MDA). Following combined treatment with the Nrf2 pathway inhibitor ML385 and TT-55, the inhibitory effects of TT-55 on inflammatory cytokines and oxidative stress markers were reversed by ML385. Meanwhile, ML385 also attenuated the ability of TT-55 to suppress LPS-induced upregulation of NLRP3 inflammasome-related genes. In conclusion, TT-55 may exert its antioxidant and anti-inflammatory effects by activating the Nrf2/HO-1 signaling pathway and suppressing the upregulation of NLRP3 inflammasome-related genes.

Indexed as

Anti-Inflammatory AgentsInflammasomesInflammationNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressAnimalsAntioxidantsCytokinesHeme Oxygenase-1LipopolysaccharidesMacrophagesMembrane ProteinsMiceNF-E2-Related Factor 2RAW 264.7 CellsReactive Oxygen SpeciesAnti-Inflammatory AgentsAntioxidantsCytokinesHeme Oxygenase-1Hmox1 protein, mouseInflammasomesLipopolysaccharidesMembrane ProteinsNfe2l2 protein, mouseNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseReactive Oxygen Speciesanti-inflammatory activitymangrove endophytic fungiNLRP3Nrf2/HO-1oxidative stressphaseolorin JRAW264.7

Identifiers

PMID42042205
PMCPMC13118055

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.