Evidence map›Paper›PMID 42042202›Full record

ArticleMarine drugs2026

Preparation of Alginate Oligosaccharides by Autoclaving Pretreatment Combined with Enzymatic Method.

Feiyu Niu, Ziqiang Gu, Zihan Yu, Zhi Bao, Jichao Li, Peng Yang, Dongyu Li, Haijin Mou, Changliang Zhu

Abstract read
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In one paragraph

Article in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Feiyu NiuCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Ziqiang GuSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Zihan YuCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Zhi BaoCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Jichao LiCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Peng YangCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Dongyu LiCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Haijin MouCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Changliang ZhuCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.

Funding

China Postdoctoral Science Foundation 2021M701547National Natural Science Foundation of China 32202064National Natural Science Foundation of China 42106110Natural Science Foundation of Jiangxi Province 20224BAB215044Shandong Province Key R&D Program 2022TZXD005Shandong Province Marine Aquaculture Innovation and Entrepreneurship Community Project YZ2024002Youth Innovation Team Program of Universities in Shandong Province 2023KJ040
6 · The paper itself

Abstract

The enzymatic method is the primary focus for alginate oligosaccharide (AOS) production. However, the high viscosity of sodium alginate (SA) substrate often limits enzymatic efficiency. Pretreatment strategies aimed at reducing SA viscosity offer a promising and innovative solution to enhance process efficiency. This study compared the effects of three pretreatment methods-high-pressure vapor (HP-v), high-pressure solution (HP-s), and atmospheric-pressure air (AP-a)-on the physicochemical properties of SA. These pretreatments reduced SA viscosity and induced visible color changes in the order HP-v > HP-s > AP-a. Additionally, the effects of high-pressure treatments on molecular weight, M/G ratio, and chemical structure of SA were analyzed, confirming the feasibility of pretreatment-assisted enzymolysis. Molecular weight distribution and ESI-MS analysis of AOS after enzymolysis demonstrated that brief HP-v treatment maximizes the catalytic potential of alginate lyase, facilitating efficient AOS production without altering its structural characteristics.

Indexed as

AlginatesOligosaccharidesPolysaccharide-LyasesGlucuronic AcidHexuronic AcidsMolecular WeightPressureViscosityAlginatesGlucuronic AcidHexuronic AcidsOligosaccharidespoly(beta-D-mannuronate) lyasePolysaccharide-Lyasesalginate oligosaccharideautoclavingenzymolysis processhigh-pressure pretreatmentsodium alginate

Identifiers

PMID42042202
PMCPMC13118009

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.