ArticleGels (Basel, Switzerland)2026
Multifunctional NIR-Responsive Composite Hydrogel with Combinatorial Antibacterial and Regenerative Properties for Diabetic Wound Healing.
Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
The management of diabetic chronic wounds (DFUs) is challenging due to persistent bacterial colonization, impaired neovascularization, and disordered inflammation. We engineered a multifunctional photothermal hydrogel (PPCS) by integrating CuS nanoparticles and high-concentration sucrose to establish a dual-action therapeutic cascade: potent antibacterial eradication followed by pro-angiogenic stimulation. Upon NIR irradiation, the PPCS system executes a combinatorial anti-infective mechanism: CuS-mediated photothermal effect and ROS generation are amplified by sucrose's hyperosmotic pressure, achieving 99.3% bacterial eradication. Beyond sterilization, the hydrogel acts as a Cu
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