Comparative Molecular Effects of Dexmedetomidine and Propofol on Osteoblast Migration and Osteogenic Gene Expression at Pediatric-Equivalent Concentrations: An In Vitro Study.

İlhan Kaya, Günseli Çubukçuoğlu Deniz, Merve Hayriye Kocaoğlu, Duru Aras Tosun, Akif Demirel

Abstract read

In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

İlhan KayaDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bursa Uludağ University, 16120 Bursa, Turkey.

Günseli Çubukçuoğlu DenizStem Cell Institute, Ankara University, 06520 Ankara, Turkey.

Merve Hayriye KocaoğluDepartment of Pediatric Dentistry, Faculty of Dentistry, Ankara University, 06560 Ankara, Turkey.ORCID 0000-0002-2259-0131

Duru Aras TosunDepartment of Basic Medical Sciences, Faculty of Dentistry, Ankara University, 06560 Ankara, Turkey.

Akif DemirelDepartment of Pediatric Dentistry, Faculty of Dentistry, Ankara University, 06560 Ankara, Turkey.ORCID 0000-0002-1433-0452

Funding

Ankara University TSA-2025-3880

6 · The paper itself

Abstract

This study compared the wound-healing response and osteogenic gene expression profile of osteoblasts exposed to pediatric-equivalent concentrations of dexmedetomidine (DXMT) and propofol (POF). Human osteoblast-like SAOS-2 cells were assigned to control, low- and high-dose DXMT and POF groups based on pharmacokinetically derived free-drug levels. Scratch-wound closure was quantified over 24 h, and expression of osteogenesis- and cytoskeleton-related genes (RANKL, RUNX2, SP7, BMP2, VIM, VCL, OCN, ALP) was measured by SYBR Green quantitative Polymerase Chain Reaction (qPCR). Normality was assessed using the Shapiro-Wilk test, and group differences were analyzed with two-way ANOVA followed by Tukey's multiple comparisons test (

Indexed as

dexmedetomidinejawbone healingosteoblastspediatric anesthesiapropofol

Identifiers

PMID42042052

DOI10.3390/cimb48040392

PMCPMC13114927

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.