Evidence map›Paper›PMID 42042037›Full record

ReviewCurrent issues in molecular biology2026

Plant-Derived Bioactive Compounds: Antioxidation, Autophagy, and Translational Applications in Skin Protection.

Liangyu Zhu, Mengsha Li, Dianwen Wei, Liping Zhou

Abstract readReview
In one paragraph

Review in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Liangyu ZhuDepartment of Natural Products Function, Institute of Natural Resources and Ecology, Heilongjiang Academy of Sciences, Harbin 150040, China.ORCID 0000-0001-6094-4845
Mengsha LiDepartment of Natural Products Function, Institute of Natural Resources and Ecology, Heilongjiang Academy of Sciences, Harbin 150040, China.
Dianwen WeiDepartment of Natural Products Function, Institute of Natural Resources and Ecology, Heilongjiang Academy of Sciences, Harbin 150040, China.
Liping ZhouDepartment of Natural Products Function, Institute of Natural Resources and Ecology, Heilongjiang Academy of Sciences, Harbin 150040, China.

Funding

Heilongjiang Postdoctoral Science Foundation LBH-Z23264National Key Research and Development Program of China during the 14th Five-Year Plan period 2022YFF1300503-03Outstanding Young Scientists Project of Heilongjiang Academy of Sciences JQ2024ZR02Scientific Research Business Expense Project of Heilongjiang Provincial Affiliated Research Institutes CZKYF2024-1-C009
6 · The paper itself

Abstract

Oxidative stress from exogenous insults is a major driver of skin aging and hyperpigmentation. Plant-derived bioactive compounds represent promising multifunctional agents with protective effects on skin. They meet the demand for natural, safe skin-protective agents with well-defined action mechanisms. However, current studies lack an integrated understanding of their dual cellular protective mechanisms: antioxidation and autophagy. A unified "component-pathway-efficacy" regulatory network remains lacking, which limits mechanistic insights into skin protection. To address this gap, this comprehensive narrative review retrieved literature from four authoritative databases: PubMed, Web of Science, Scopus, and Wiley Online Library. With targeted keyword retrieval, 129 core studies published between 2021 and 2025 were selected for synthesis. The selection was based on relevance, methodological rigor, and scientific impact. This review constructs a novel "antioxidation-autophagy" synergistic regulatory model. It also establishes a consolidated dual-mechanism framework outlining the "component-pathway-efficacy" axis. This framework reduces knowledge fragmentation across natural product research, skin biology and translational molecular biology. This work integrates the dual protective mechanisms of plant-derived bioactive compounds for skin protection and translational applications. It provides a theoretical basis for understanding their molecular regulatory logic and facilitates further mechanistic studies and translational research on skin protection.

Indexed as

antioxidationautophagybifunctional ingredientsoxidative stressplant-derived bioactive compoundsskin protection mechanismstranslational applications

Identifiers

PMID42042037
PMCPMC13114311

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.