Evidence map›Paper›PMID 42042036›Full record

ArticleCurrent issues in molecular biology2026

In Silico and In Vitro Investigation of Apoptosis-Mediated Antiproliferative Activity of Capsaicin and Alpha-Lipoic Acid Against Prostate Cancer Cells.

Ogunc Meral, Burcu Menekse Balkan, Dilek Nur Bestil, Serkan Sayiner, Deniz Ceylanli, Sare Uyurca, Sinem Pehlivan, Guzin Ozkurt, Gorkem Kismali, Tevhide Sel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ogunc MeralDepartment of Biochemistry, Faculty of Veterinary Medicine, Ankara University, Ankara 06070, Turkey.ORCID 0000-0001-8813-4991
Burcu Menekse BalkanDepartment of Biochemistry, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur 15200, Turkey.
Dilek Nur BestilDepartment of Biochemistry, Institute of Health Science, Ankara University, Ankara 06070, Turkey.ORCID 0000-0003-1565-1466
Serkan SayinerDepartment of Biochemistry, Faculty of Veterinary Medicine, Near East University, Nicosia 99138, North Cyprus, Mersin-10, Turkey.ORCID 0000-0002-3297-5369
Deniz CeylanliDepartment of Biochemistry, Faculty of Veterinary Medicine, Near East University, Nicosia 99138, North Cyprus, Mersin-10, Turkey.ORCID 0000-0003-2352-052X
Sare UyurcaDepartment of Biochemistry, Faculty of Medicine, Duzce University, Duzce 81620, Turkey.
Sinem PehlivanDepartment of Medical Pharmacology, School of Medicine, Ankara Medipol University, Ankara 06050, Turkey.
Guzin OzkurtDepartment of Biochemistry, Faculty of Veterinary Medicine, Aksaray University, Aksaray 68100, Turkey.
Gorkem KismaliDepartment of Biochemistry, Faculty of Veterinary Medicine, Ankara University, Ankara 06070, Turkey.
Tevhide SelDepartment of Biochemistry, Faculty of Veterinary Medicine, Ankara University, Ankara 06070, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products are widely used in the treatment of cancer due to the side effects of chemotherapeutics, and a large number of natural compounds have been reported to have anticancer activities in different types of cancer. The aim of the study was to analyze the antiproliferative and apoptotic effects of capsaicin and alpha-lipoic acid on prostate cancer cells in silico and in vitro. The effects of capsaicin and alpha-lipoic acid on the proliferation of prostate cancer cells were assessed using MTT cell viability assays. Apoptotic protein levels were measured using Western blot analysis. Ligand-protein potential interactions of alpha-lipoic acid and capsaicin with survivin and bax proteins were examined using CB-Dock2 and SwissDock software. Capsaicin and alpha-lipoic acid significantly inhibited the proliferation of both prostate cancer cell lines in a dose- and time-dependent manner. Our data revealed that various concentrations of capsaicin, alpha-lipoic acid and their combinations caused remarkable downregulation of survivin expression on prostate cancer cells. According to the Vina scores, alpha-lipoic acid and capsaicin have the potential to interact strongly with survivin and bax proteins. We suggest that both natural compounds have the potential for treating prostate cancer according to the in vitro and in silico results.

Indexed as

alpha-lipoic acidapoptosiscapsaicinprostate cancersurvivin

Identifiers

PMID42042036
PMCPMC13115366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.