Evidence map›Paper›PMID 42042034›Full record

ArticleCurrent issues in molecular biology2026

Bioactive Peptides from Yellowfin Tuna By-Products: Structural Characterization and Neuro-Related Activities in PC12 Cells.

Yaqi Kong, Yifan Liu, Haoze Yang, Xianzhe Liang, Min Zhao, Ahsan Javed, Xiaozhen Diao, Wenhui Wu

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In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yaqi KongDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Yifan LiuDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Haoze YangDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Xianzhe LiangDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Min ZhaoDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Ahsan JavedDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.ORCID 0000-0002-6930-1958
Xiaozhen DiaoDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.ORCID 0000-0003-1805-5408
Wenhui WuDepartment of Marine Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.ORCID 0000-0002-1710-8582

Funding

the National Natural Science Foundation of China No.82173731the Scientific Research Project of Shanghai International Science and Technology Cooperation Fund Project No.17490742500
6 · The paper itself

Abstract

Marine-derived bioactive peptides have attracted increasing attention as value-added functional ingredients. In this study, peptides (<3 kDa) were prepared from yellowfin tuna processing by-products and further fractionated by Sephadex G-25 gel filtration. The major fraction (TBP-MF) exhibited markedly improved compositional homogeneity compared with the unfractionated hydrolysate (TBP), providing a well-defined peptide system for subsequent characterization and biological evaluation. Physicochemical analyses demonstrated that TBP-MF possessed enhanced thermal stability and a more ordered secondary structure, characterized by pronounced β-sheet enrichment, as revealed by TGA/DSC, FTIR, and circular dichroism analyses. Morphological and colloidal characterization further showed that TBP-MF formed relatively uniform lamellar and fibrous assemblies with a narrower particle size distribution and reduced electrostatic stabilization, indicating a higher tendency toward ordered self-association. Peptidomic profiling combined with in silico analysis revealed that TBP-MF was enriched in short peptides with relatively higher PeptideRanker scores and a functional motif distribution containing relatively more neuro-related annotations, although angiotensin-converting enzyme (ACE)- and dipeptidyl peptidase IV (DPP-IV)-related motifs remained predominant in both groups. In differentiated PC12 cells, TBP-MF exhibited excellent cytocompatibility and induced a stable, concentration-dependent increase in the Cell Counting Kit-8 (CCK-8) readout (OD

Indexed as

bioactive peptidesneuro-related activityPC12 cellsyellowfin tuna by-products

Identifiers

PMID42042034
PMCPMC13114659

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.