ArticleCurrent issues in molecular biology2026
Different Effects of Antioxidants Against Ionizing Radiation: An Experimental Model of Micronuclei.
Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
There is an urgent need to find and develop radiation countermeasures for both planned and unplanned exposures. However, in recent years, radioprotective substances, such as rosmarinic acid (RA), have been described, presenting contradictory and even paradoxical results. In this paper, we evaluated the genoprotective capacity of 29 substances against chromosomal damage induced by gamma radiation in a comparative study using the same technique, i.e., cytokinesis-block micronucleus (CBMN) assay to evaluate their genoprotective capacities, at the same concentrations and administered before and after exposure to 2 Gy of gamma radiation. We then related the observed effects with their chemical characteristics to appreciate the different mechanisms of action that could explain some apparent contradictions that may emerge. In our study, before exposure to ionizing radiation, RA produced the greatest reduction in the frequency of radiation-induced micronuclei (
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