ReviewCurrent issues in molecular biology2026
Host Factors Potentially Contributing to Increased Susceptibility in Certain Layer Chicken Lines.
Review in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
12 authors.
Funding
Abstract
Avian influenza (AI) continues to threaten global poultry production, with accumulating evidence suggesting that certain commercial layer lines may exhibit increased susceptibility under specific experimental conditions compared with broiler chickens. This narrative review synthesizes published experimental infection studies identified through a comprehensive PubMed search, focusing on low pathogenic H9N2 and highly pathogenic H5N1, H5N2, H7N7, and H7N9 viruses. Although bird age and production stage varied across studies, consistent disparities in immune regulation and viral replication dynamics have been reported. We critically evaluate host determinants underlying these differences-including microRNAs, major histocompatibility complex polymorphisms, sialic acid receptor distribution, gut microbiota, and hormonal influences-and integrate findings across viral subtypes and pathogenicity classes to inform breed-tailored vaccination, nutritional, and therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.