ArticleCurrent issues in molecular biology2026
S-Doped Carbon Dot Treatment Alters RNA Processing, Translation, and Protein Degradation Pathways in HeLa Cells.
Katarina Davalieva, Vanja Ralić, Gjorgji Bozhinovski, Branislava Gemović, Maja D Nešić, Lela Korićanac, Tanja Dučić, Manuel Algarra, Iva A Popović, Milutin Stepić and 1 more
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In one paragraphArticle in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Katarina DavalievaResearch Centre for Genetic Engineering and Biotechnology "Georgi D Efremov", Macedonian Academy of Sciences and Arts, 1000 Skopje, North Macedonia.ORCID 0000-0002-0878-6533 Vanja RalićCOHERENCE Centre, Department of Atomic Physics, VINČA Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-3206-1831 Gjorgji BozhinovskiResearch Centre for Genetic Engineering and Biotechnology "Georgi D Efremov", Macedonian Academy of Sciences and Arts, 1000 Skopje, North Macedonia.
Branislava GemovićDepartment for Bioinformatics and Computational Chemistry, VINČA Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-8987-020X Maja D NešićCOHERENCE Centre, Department of Atomic Physics, VINČA Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-9167-6553 Lela KorićanacDepartment of Molecular Biology and Endocrinology, VINČA Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0001-5497-284X Tanja DučićALBA-CELLS Synchrotron Light Source, Consorcio para la Construcción Equipamiento y Explotación, Del Laboratorio de Luz Sincrotron, 08290 Cerdanyola del Vallés, Spain.ORCID 0000-0003-2389-3887 Manuel AlgarraINAMAT2-Institute for Advanced Materials and Mathematics, Department of Science, Public University of Navarra, 31006 Pamplona, Spain.ORCID 0000-0003-2410-8430 Iva A PopovićCOHERENCE Centre, Department of Atomic Physics, VINČA Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0003-1120-8985 Milutin StepićCOHERENCE Centre, Department of Atomic Physics, VINČA Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-0623-5113 Marijana PetkovićCOHERENCE Centre, Department of Atomic Physics, VINČA Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-8354-995X Funding
Ministry of Science, Technological Development, and Innovation of the Republic of Serbia 451-03-136/2025-03/200017MIRAS beamline at the ALBA Synchrotron experiment Nos. 2022025758 and 2023027403Spanish Ministry of Science and Innovation (MCIN/AEI/10, 13039/501100011033) through project PID2021-122613OB-I00Western Balkans Fund Move Grants PROMETHEAN I MO-1-041, and PROMETHEAN II MO-5-084
6 · The paper itselfAbstract
Carbon dots offer excellent physico-chemical properties and biocompatibility for cancer theranostics systems, either as therapeutic agents themselves, or as potential drug carriers. It is, however, postulated that the drug carrier affects the mechanism of action and intracellular target molecules of a drug. Therefore, in the present study, we systematically evaluated protein alterations in HeLa cervical cancer cells after treatment with sulfur-doped carbon dots (S-CDs). Synchrotron Radiation μFTIR spectroscopy and label-free LC-MS/MS proteomics integrated with bioinformatics were used to assess molecular changes. μFTIR revealed a shift and increased intensity of α-helices, indicating structural changes in proteins as a result of the interaction between S-CDs and cells. Proteomic analysis identified 122 statistically significant (
Indexed as
bioinformaticsproteomicsribosomesS-doped carbon dotsµFTIR
Identifiers
PMID42042009
PMCPMC13114559
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