Evidence map›Paper›PMID 42041933›Full record

ArticleBiology2026

Altered Hippocampal Clock Gene Regulation Is Associated with Circadian Dysregulation of Oxidative Imbalance, Neuroinflammation, and Histopathological Damage After Pinealectomy.

Venhar Gurbuz Can, Mehmet Demir, Tansu Kusat, Feyza Basak

Erratum issuedAbstract read
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Venhar Gurbuz CanDepartment of Medical Biology, Faculty of Medicine, Karabuk University, Karabuk 78050, Turkey.ORCID 0000-0002-9777-5173
Mehmet DemirDepartment of Physiology, Faculty of Medicine, Karabuk University, Karabuk 78050, Turkey.
Tansu KusatDepartment of Histology and Embryology, Faculty of Medicine, Karabuk University, Karabuk 78050, Turkey.ORCID 0000-0001-7237-1562
Feyza BasakDepartment of Histology and Embryology, Faculty of Medicine, Karabuk University, Karabuk 78050, Turkey.

Funding

Karabük University KBÜBAP-25-DS-056
6 · The paper itself

Abstract

Pinealectomy leads to melatonin deficiency, which is known to disrupt circadian clock regulation and may increase vulnerability of the hippocampus to oxidative stress and neuroinflammatory processes. The objective of this study was to examine the gene expression levels of circadian locomotor output cycles kaput (CLOCK), brain and muscle ARNT-like 1 (BMAL1), period circadian regulator 1 (PER1), cryptochrome circadian regulator 1 (CRY1), brain-derived neurotrophic factor (BDNF), and interleukin-6 (IL-6) in the hippocampus to elucidate the impact of pinealectomy-induced circadian dysregulation on these gene expressions and to assess its association with hippocampal alterations. A total of 30 Wistar rats were randomly divided into three groups: Control, Sham, and Pinealectomy (PNX) (

Indexed as

clock genesimmunohistochemistryneuroinflammationoxidative stresspinealectomy

Identifiers

PMID42041933
PMCPMC13114143

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.