Evidence map›Paper›PMID 42041923›Full record

ArticleBiology2026

Maternal Methyl Donor Nutrients Modulate Developmental Genes in Mammary Tumors.

Lawrence Mabasa, Anri Kotze, Rabia Johnson, Pritika Ramharack, Sylvester I Omoruyi, Kwazikwakhe B Gabuza, Jyoti Sharma, Tarryn Willmer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lawrence MabasaBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, Cape Town 7505, South Africa.ORCID 0000-0001-6499-3396
Anri KotzeBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, Cape Town 7505, South Africa.
Rabia JohnsonBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, Cape Town 7505, South Africa.ORCID 0000-0002-6328-0789
Pritika RamharackBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, Cape Town 7505, South Africa.ORCID 0000-0001-5850-6782
Sylvester I OmoruyiDepartment of Anatomical Sciences, School of Biomedical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.ORCID 0000-0002-1119-7780
Kwazikwakhe B GabuzaBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, Cape Town 7505, South Africa.ORCID 0000-0003-0144-6664
Jyoti SharmaBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, Cape Town 7505, South Africa.ORCID 0000-0003-0170-7342
Tarryn WillmerBiomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, Cape Town 7505, South Africa.ORCID 0000-0002-6191-7440

Funding

National Research Foundation 121859 and TTK230508103541
6 · The paper itself

Abstract

Maternal nutrition during critical windows of development plays a pivotal role in shaping long-term disease susceptibility, including cancer risk. This study investigated whether maternal exposure to lipotropes (methyl donor nutrients) during pregnancy and lactation modulates gene expression in 7,12-dimethylbenzanthracene (DMBA)-induced mammary tumors in adult female offspring. Timed-pregnant Sprague-Dawley rats were fed with either a control or lipotrope-supplemented diet, with or without vitamin B6. Female offspring were exposed to DMBA at puberty, and mammary tumors were evaluated histologically and molecularly. DMBA-induced tumors displayed ductal carcinoma in situ-like morphology and significant upregulation of fetal mammary developmental genes (

Indexed as

childDNA methylationDOHaDepigeneticslipotropesmammary developmentmaternalmethyl donor nutrientsmicronutrientsmotherone-carbon metabolism

Identifiers

PMID42041923
PMCPMC13112942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.