Evidence map›Paper›PMID 42041915›Full record

ArticleBiology2026

Umbilical Cord PRP Accelerates Corneal Wound Healing via AQP1 Upregulation and Calcium Signaling.

Simona Martinotti, Giorgia Pellavio, Gregorio Bonsignore, Valeria Balbo, Laura Mazzucco, Umberto Laforenza, Elia Ranzato

Abstract read
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Simona MartinottiDiSIT-Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, Viale Teresa Michel 11, 15121 Alessandria, Italy.ORCID 0000-0003-2891-1810
Giorgia PellavioHuman Physiology Unit, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.
Gregorio BonsignoreDiSIT-Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, Viale Teresa Michel 11, 15121 Alessandria, Italy.ORCID 0000-0003-0225-5763
Valeria BalboTransfusion Medicine and Regeneration Medicine, Azienda Universitaria Ospedaliera "SS Antonio e Biagio e Cesare Arrigo", Via Venezia, 16, 15121 Alessandria, Italy.ORCID 0009-0000-2923-5389
Laura MazzuccoTransfusion Medicine and Regeneration Medicine, Azienda Universitaria Ospedaliera "SS Antonio e Biagio e Cesare Arrigo", Via Venezia, 16, 15121 Alessandria, Italy.
Umberto LaforenzaHuman Physiology Unit, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0003-2951-5983
Elia RanzatoDiSIT-Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, Viale Teresa Michel 11, 15121 Alessandria, Italy.ORCID 0000-0002-7600-8215

Funding

Fondazione CRT (Collirio biologico da Concentrato Piastrinico da Sangue Cordonale: una nuo-va possibile terapia per la secchezza oculare (Protocollo: 2019.AI1619.U1833) (Protocollo: 2019.AI1619.U1833)NextGeneration EU and Compagnia di San Paolo NextGeneration EU and Compagnia di San Paolo
6 · The paper itself

Abstract

Umbilical cord-derived Platelet-Rich Plasma (ucPRP) promotes corneal regeneration, yet the underlying cellular mechanisms remain incompletely understood. This study evaluated the effects of ucPRP on corneal epithelial cell physiology and wound healing dynamics. In scratch assays, ucPRP treatment significantly accelerated wound closure by enhancing cell migration and proliferation. Confocal microscopy using Fluo-3 demonstrated that ucPRP induces transient increases in intracellular calcium (Ca

Indexed as

aquaporincalcium signalinghydrogen peroxidemigrationproliferationwater permeability

Identifiers

PMID42041915
PMCPMC13113299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.