Evidence map›Paper›PMID 42041835›Full record

ReviewBrain sciences2026

Brain Organoids: Emerging Platforms for Modern Neuroscience.

Lian Wang, Liwei Mao, Qing Cao, Xuemei Zong

Abstract readReview
In one paragraph

Review in Brain sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lian WangDepartment of Neurology, Institute for Cerebrovascular and Neuroregeneration Research (ICNR), Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA.ORCID 0000-0002-0004-9440
Liwei MaoDepartment of Neurology, Institute for Cerebrovascular and Neuroregeneration Research (ICNR), Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA.ORCID 0000-0002-1406-8183
Qing CaoDepartment of Neurology, David Geffen School of Medicine, University of California, 710 Westwood Plaza, Los Angeles, CA 90095, USA.
Xuemei ZongDepartment of Neurology, Institute for Cerebrovascular and Neuroregeneration Research (ICNR), Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA.ORCID 0000-0003-0010-1664

Funding

American Heart Association 24CDA1269588
6 · The paper itself

Abstract

Brain organoids represent three-dimensional structures that allow for human-specific studies in brain development, pathology and therapeutics. These self-organizing systems, formed through the differentiation of human pluripotent stem cells, can mimic important cellular and molecular events of brain development and therefore serve as a platform for the investigation of neurodevelopmental and neurodegenerative diseases, brain injuries, and tumorigenesis. Although brain organoids show promising perspectives in the study of human physiology, existing brain organoid platforms are hindered by issues of under vascularization, immaturity and protocol variability. Nevertheless, the rapid development of new bioengineering, microfluidic and multi-omics tools and approaches allows us to overcome existing problems and increase the physiological significance of these organoids. Brain organoid transplantation and functional studies further enhance the applications of brain organoids in drug screening, disease modeling and personalized medicine. Here, we provide an overview of recent developments in the field of brain organoid cultures, functional characteristics and translational applications.

Indexed as

3D culture systemsbioengineeringbrain organoidsdisease modelingneural developmentorganoid transplantation

Identifiers

PMID42041835
PMCPMC13114865

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.