Evidence map›Paper›PMID 42041724›Full record

ArticleCurrent oncology (Toronto, Ont.)2026

Instability in Pentanucleotide Markers in a Subset of Microsatellite Instability-High Colorectal Cancer.

Ahmet Yilmaz, Wendy L Frankel, Benjamin J Swanson, Kristin Miller, Jason Bacher, Christopher Bigley, Lori Nelsen, Matthew F Kalady, Joshua F Coleman, Rachel Pearlman and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ahmet YilmazDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Wendy L FrankelDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Benjamin J SwansonDepartment of Pathology, Microbiology, and Immunology, The University of Nebraska Medical Center, Omaha, NE 68198, USA.
Kristin MillerDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Jason BacherDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Christopher BigleyDivision of Human Genetics, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID 0009-0009-1565-4342
Lori NelsenDivision of Human Genetics, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Matthew F KaladyDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Joshua F ColemanDepartment of Pathology, University of Utah, Salt Lake City, UT 84112, USA.
Rachel PearlmanDivision of Human Genetics, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Heather HampelDivision of Clinical Cancer Genomics, Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0001-7558-9794

Funding

This study was supported by a grant from Pelotonia, an annual cycling event held in Columbus, OH. No grant number.
6 · The paper itself

Abstract

Microsatellite instability (MSI) testing is frequently used to screen patients for the early detection of Lynch syndrome, the most common hereditary colorectal cancer syndrome. MSI testing compares microsatellite repeat lengths in tumor DNA with those in matched normal tissue from the same patient. Therefore, precise sample identification is critical for obtaining reliable test results. The Penta-C and Penta-D pentanucleotide markers are widely used for sample identification in MSI testing. We investigated instability, defined as allelic mismatches or shifts, discordant fragment sizes, or the appearance of alleles in tumor DNA that were absent in the corresponding normal DNA, in the Penta-C and Penta-D loci across 2609 paired colorectal tumor and matched normal tissue or blood DNA samples. The allele sizes of both markers did not match in 0.3% of microsatellite-stable (MSS) and 12.3% of microsatellite instability-high (MSI-H) patients (

Indexed as

Colorectal NeoplasmsMicrosatellite InstabilityMicrosatellite RepeatsFemaleHumanscolorectal cancerDNA mismatch repairIHCimmunohistochemistrymicrosatellite instabilityMMRMSIpentanucleotideshort tandem repeatsSTR

Identifiers

PMID42041724
PMCPMC13114762

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.