Evidence map›Paper›PMID 42041599›Full record

ArticleCells2026

Sphingolipid Expression During Corneal Wound Healing in a Sphingosine Kinase 1 Knockout Model.

Sandip K Basu, Steve Mabry, Peter Nsiah, Sarah E Nicholas, Nataliya Lenchik, Mark Altawil, Chi-Yang Chiu, Daniel J Stephenson, Charles E Chalfant, Dimitrios Karamichos and 1 more

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sandip K BasuDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Steve MabryNorth Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Peter NsiahNorth Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0009-0000-0467-5492
Sarah E NicholasNorth Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0002-1187-4964
Nataliya LenchikDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Mark AltawilDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Chi-Yang ChiuDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Daniel J StephensonDepartments of Medicine and Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Charles E ChalfantDepartments of Medicine and Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.ORCID 0000-0002-5844-5235
Dimitrios KaramichosNorth Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0002-8761-3824
Nawajes MandalDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-4489-7748

Funding

Ceramides and Sphingolipids as Predictors of Incident DysglycemiaR01DK128129 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DAGOGO-JACK, M.D., D.SC., SAMUEL, MANDAL, NAWAJES · 2021 to 2024
$2.0M
Sphingolipids and their Impact in Corneal Wound HealingR01EY031316 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KARAMICHOS, DIMITRIOS, MANDAL, NAWAJES · 2020 to 2023
$1.8M
BLRD VA I01 BX004893Department of Veterans Affairs Biomedical Laboratory R&D BX004893Knights Templar Eye Foundation Career Starter Research GrantNEI NIH HHS R01 EY031316NIDDK NIH HHS R01 DK128129NIH HHS 5R01DK128129-04NIH HHS 5R01EY031316-04Research to Prevent Blindness N/AUS Department of Defense, Office of the CDMRP, VRP W81XWH-20-1-0900
6 · The paper itself

Abstract

Corneal scarring is a result of unregulated fibrotic processes in wound healing, which causes visual impairment. Bioactive sphingolipids (SPLs) are known to modulate physiological processes that are central to wound healing. Of these bioactive SPLs, sphingosine-1-phosphate (S1P) is perhaps the most studied. Previous research has shown that knocking out sphingosine kinase 1 (Sphk1), which produces S1P, alters SPL species metabolism and improves wound healing in mice corneas. However, it is unknown how SphK1 knockout (

Indexed as

CorneaCorneal InjuriesPhosphotransferases (Alcohol Group Acceptor)SphingolipidsWound HealingAnimalsDisease Models, AnimalLysophospholipidsMiceMice, Inbred C57BLMice, KnockoutSphingosineSphingosine KinaseLysophospholipidsPhosphotransferases (Alcohol Group Acceptor)SphingolipidsSphingosinesphingosine 1-phosphateSphingosine KinaseSphk1 protein, mouseceramidecorneasphingolipidssphingosine-1-phosphatesphingosine kinase 1wound healing

Identifiers

PMID42041599
PMCPMC13115462

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.